TY - JOUR
T1 - A pentose bisphosphate pathway for nucleoside degradation in Archaea
AU - Aono, Riku
AU - Sato, Takaaki
AU - Imanaka, Tadayuki
AU - Atomi, Haruyuki
N1 - Funding Information:
This study was funded by the Core Research for Evolutional Science and Technology program of the Japan Science and Technology Agency to H.A. within the research area ‘Creation of Basic Technology for Improved Bioenergy Production through Functional Analysis and Regulation of Algae and Other Aquatic Microorganisms’. R.A. is a Research Fellow of the Japan Society for the Promotion of Science.
Publisher Copyright:
© 2015 Nature America, Inc. All rights reserved.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Owing to the absence of the pentose phosphate pathway, the degradation pathway for the ribose moieties of nucleosides is unknown in Archaea. Here, in the archaeon Thermococcus kodakarensis, we identified a metabolic network that links the pentose moieties of nucleosides or nucleotides to central carbon metabolism. The network consists of three nucleoside phosphorylases, an ADP-dependent ribose-1-phosphate kinase and two enzymes of a previously identified NMP degradation pathway, ribose-1,5-bisphosphate isomerase and type III ribulose-1,5-bisphosphate carboxylase/oxygenase. Ribose 1,5-bisphosphate and ribulose 1,5-bisphosphate are intermediates of this pathway, which is thus designated the pentose bisphosphate pathway.
AB - Owing to the absence of the pentose phosphate pathway, the degradation pathway for the ribose moieties of nucleosides is unknown in Archaea. Here, in the archaeon Thermococcus kodakarensis, we identified a metabolic network that links the pentose moieties of nucleosides or nucleotides to central carbon metabolism. The network consists of three nucleoside phosphorylases, an ADP-dependent ribose-1-phosphate kinase and two enzymes of a previously identified NMP degradation pathway, ribose-1,5-bisphosphate isomerase and type III ribulose-1,5-bisphosphate carboxylase/oxygenase. Ribose 1,5-bisphosphate and ribulose 1,5-bisphosphate are intermediates of this pathway, which is thus designated the pentose bisphosphate pathway.
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U2 - 10.1038/nchembio.1786
DO - 10.1038/nchembio.1786
M3 - Article
C2 - 25822915
AN - SCOPUS:84932154977
SN - 1552-4450
VL - 11
SP - 355
EP - 360
JO - Nature Chemical Biology
JF - Nature Chemical Biology
IS - 5
ER -