A pentose bisphosphate pathway for nucleoside degradation in Archaea

Riku Aono, Takaaki Sato, Tadayuki Imanaka, Haruyuki Atomi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Owing to the absence of the pentose phosphate pathway, the degradation pathway for the ribose moieties of nucleosides is unknown in Archaea. Here, in the archaeon Thermococcus kodakarensis, we identified a metabolic network that links the pentose moieties of nucleosides or nucleotides to central carbon metabolism. The network consists of three nucleoside phosphorylases, an ADP-dependent ribose-1-phosphate kinase and two enzymes of a previously identified NMP degradation pathway, ribose-1,5-bisphosphate isomerase and type III ribulose-1,5-bisphosphate carboxylase/oxygenase. Ribose 1,5-bisphosphate and ribulose 1,5-bisphosphate are intermediates of this pathway, which is thus designated the pentose bisphosphate pathway.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalNature Chemical Biology
Issue number5
Publication statusPublished - 2015 May 1
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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