A possible function of DNA curvature in transcription.

T. Ohyama; Y. Hirota

A possible function of DNA curvature in transcription.

Research output: Contribution to journal › Article › peer-review

Abstract

The region preceding the beta-lactamase promoter of Escherichia coli plasmid pUC19 has a DNA curvature (curved DNA or bent DNA). Studies using mutant plasmids showed that the curved DNA structure is required for efficient transcription of the beta-lactamase gene and suggested that the requisite shape is a small part of a right-handed coil. Based on these results, the possible functional significance of DNA curvature in transcription will be discussed.

Original language	English
Pages (from-to)	153-154
Number of pages	2
Journal	Nucleic acids symposium series
Issue number	29
Publication status	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "A possible function of DNA curvature in transcription.",

abstract = "The region preceding the beta-lactamase promoter of Escherichia coli plasmid pUC19 has a DNA curvature (curved DNA or bent DNA). Studies using mutant plasmids showed that the curved DNA structure is required for efficient transcription of the beta-lactamase gene and suggested that the requisite shape is a small part of a right-handed coil. Based on these results, the possible functional significance of DNA curvature in transcription will be discussed.",

author = "T. Ohyama and Y. Hirota",

year = "1993",

language = "English",

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journal = "Nucleic acids symposium series",

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AU - Hirota, Y.

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AB - The region preceding the beta-lactamase promoter of Escherichia coli plasmid pUC19 has a DNA curvature (curved DNA or bent DNA). Studies using mutant plasmids showed that the curved DNA structure is required for efficient transcription of the beta-lactamase gene and suggested that the requisite shape is a small part of a right-handed coil. Based on these results, the possible functional significance of DNA curvature in transcription will be discussed.

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