Abstract
The region preceding the beta-lactamase promoter of Escherichia coli plasmid pUC19 has a DNA curvature (curved DNA or bent DNA). Studies using mutant plasmids showed that the curved DNA structure is required for efficient transcription of the beta-lactamase gene and suggested that the requisite shape is a small part of a right-handed coil. Based on these results, the possible functional significance of DNA curvature in transcription will be discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 153-154 |
| Number of pages | 2 |
| Journal | Nucleic acids symposium series |
| Issue number | 29 |
| Publication status | Published - 1993 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)