Abstract
The region preceding the beta-lactamase promoter of Escherichia coli plasmid pUC19 has a DNA curvature (curved DNA or bent DNA). Studies using mutant plasmids showed that the curved DNA structure is required for efficient transcription of the beta-lactamase gene and suggested that the requisite shape is a small part of a right-handed coil. Based on these results, the possible functional significance of DNA curvature in transcription will be discussed.
Original language | English |
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Pages (from-to) | 153-154 |
Number of pages | 2 |
Journal | Nucleic acids symposium series |
Issue number | 29 |
Publication status | Published - 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)