Abstract
The region preceding the beta-lactamase promoter of Escherichia coli plasmid pUC19 has a DNA curvature (curved DNA or bent DNA). Studies using mutant plasmids showed that the curved DNA structure is required for efficient transcription of the beta-lactamase gene and suggested that the requisite shape is a small part of a right-handed coil. Based on these results, the possible functional significance of DNA curvature in transcription will be discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 153-154 |
| Number of pages | 2 |
| Journal | Nucleic acids symposium series |
| Issue number | 29 |
| Publication status | Published - 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
A possible function of DNA curvature in transcription. / Ohyama, Takashi; Hirota, Y.
In: Nucleic acids symposium series, No. 29, 1993, p. 153-154.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A possible function of DNA curvature in transcription.
AU - Ohyama, Takashi
AU - Hirota, Y.
PY - 1993
Y1 - 1993
N2 - The region preceding the beta-lactamase promoter of Escherichia coli plasmid pUC19 has a DNA curvature (curved DNA or bent DNA). Studies using mutant plasmids showed that the curved DNA structure is required for efficient transcription of the beta-lactamase gene and suggested that the requisite shape is a small part of a right-handed coil. Based on these results, the possible functional significance of DNA curvature in transcription will be discussed.
AB - The region preceding the beta-lactamase promoter of Escherichia coli plasmid pUC19 has a DNA curvature (curved DNA or bent DNA). Studies using mutant plasmids showed that the curved DNA structure is required for efficient transcription of the beta-lactamase gene and suggested that the requisite shape is a small part of a right-handed coil. Based on these results, the possible functional significance of DNA curvature in transcription will be discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027422683&partnerID=8YFLogxK
M3 - Article
C2 - 8247748
AN - SCOPUS:0027422683
SP - 153
EP - 154
JO - Nucleic acids symposium series
JF - Nucleic acids symposium series
SN - 0261-3166
IS - 29
ER -