A possible function of DNA curvature in transcription.

T. Ohyama, Y. Hirota

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Abstract

The region preceding the beta-lactamase promoter of Escherichia coli plasmid pUC19 has a DNA curvature (curved DNA or bent DNA). Studies using mutant plasmids showed that the curved DNA structure is required for efficient transcription of the beta-lactamase gene and suggested that the requisite shape is a small part of a right-handed coil. Based on these results, the possible functional significance of DNA curvature in transcription will be discussed.

Original languageEnglish
Pages (from-to)153-154
Number of pages2
JournalNucleic acids symposium series
Issue number29
Publication statusPublished - 1993

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ASJC Scopus subject areas

  • Medicine(all)

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