A Proposed Molecular Mechanism for Physical Analgesia in Chronic Pain

Norio Saito, Rei Shima, Yurika Yamada, Masaru Nagaoka, Etsuro Ito, Tohru Yoshioka

    Research output: Contribution to journalReview article

    1 Citation (Scopus)

    Abstract

    Although pain is indispensable for survival, chronic pain places a heavy burden on humans. As the efficacy of opioid treatment is limited, the development of alternative methods of pain relief without medication is desirable. Recently, we have developed a novel method of physical analgesia using an adhesive "pyramidal thorn patch." When we apply about 3 trials of these patches on the skin of a pain region, the pain region moves toward the spinal cord like a "cutaneous rabbit," and finally, the pain vanishes. In the present review, we propose a molecular mechanism for this analgesic method or pain relief following application of the pyramidal thorn patch where firstly the mechanoreceptors and their related nerves under the skin are activated in response to touch. Transient receptor potential (TRP) channels serve as mechanosensitive channels within these mechanoreceptors. We further propose that activation of the nerves connected with the mechanoreceptors releases oxytocin, which has an antinociceptive function and activates TRP channels to hyperpolarize the pain signal nerves. We believe that our system will pave the way for alternative pain treatment.

    Original languageEnglish
    Article number1260285
    JournalNeural Plasticity
    Volume2018
    DOIs
    Publication statusPublished - 2018 Jan 1

    Fingerprint

    Chronic Pain
    Analgesia
    Pain
    Mechanoreceptors
    Transient Receptor Potential Channels
    Skin
    Touch
    Neuralgia
    Oxytocin
    Adhesives
    Opioid Analgesics
    Analgesics
    Spinal Cord
    Rabbits
    Survival

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology

    Cite this

    Saito, N., Shima, R., Yamada, Y., Nagaoka, M., Ito, E., & Yoshioka, T. (2018). A Proposed Molecular Mechanism for Physical Analgesia in Chronic Pain. Neural Plasticity, 2018, [1260285]. https://doi.org/10.1155/2018/1260285

    A Proposed Molecular Mechanism for Physical Analgesia in Chronic Pain. / Saito, Norio; Shima, Rei; Yamada, Yurika; Nagaoka, Masaru; Ito, Etsuro; Yoshioka, Tohru.

    In: Neural Plasticity, Vol. 2018, 1260285, 01.01.2018.

    Research output: Contribution to journalReview article

    Saito, N, Shima, R, Yamada, Y, Nagaoka, M, Ito, E & Yoshioka, T 2018, 'A Proposed Molecular Mechanism for Physical Analgesia in Chronic Pain', Neural Plasticity, vol. 2018, 1260285. https://doi.org/10.1155/2018/1260285
    Saito, Norio ; Shima, Rei ; Yamada, Yurika ; Nagaoka, Masaru ; Ito, Etsuro ; Yoshioka, Tohru. / A Proposed Molecular Mechanism for Physical Analgesia in Chronic Pain. In: Neural Plasticity. 2018 ; Vol. 2018.
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