A protonic biotransducer controlling mitochondrial ATP synthesis

Z. Zhang, H. Kashiwagi, S. Kimura, S. Kong, Y. Ohta, Takeo Miyake

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In nature, protons (H+) play an important role in biological activities such as in mitochondrial ATP synthesis, which is driven by a H+ gradient across the inner membrane, or in the activation of acid sensing ion channels in neuron cells. Bioprotonic devices directly interface with the H+ concentration (pH) to facilitate engineered interactions with these biochemical processes. Here we develop a H+ biotransducer that changes the pH in a mitochondrial matrix by controlling the flow of H+ between a conductive polymer of sulfonated polyaniline and solution. We have successfully modulated the rate of ATP synthesis in mitochondria by altering the solution pH. Our H+ biotransducer provides a new way to monitor and modulate pH dependent biological functions at the interface between the electronic devices and biological materials.

Original languageEnglish
Article number10423
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Acid Sensing Ion Channels
Adenosine Triphosphate
Mitochondria
Bioactivity
Biological materials
Neurons
Protons
Polymers
Chemical activation
Membranes
polyaniline

ASJC Scopus subject areas

  • General

Cite this

A protonic biotransducer controlling mitochondrial ATP synthesis. / Zhang, Z.; Kashiwagi, H.; Kimura, S.; Kong, S.; Ohta, Y.; Miyake, Takeo.

In: Scientific Reports, Vol. 8, No. 1, 10423, 01.12.2018.

Research output: Contribution to journalArticle

Zhang, Z. ; Kashiwagi, H. ; Kimura, S. ; Kong, S. ; Ohta, Y. ; Miyake, Takeo. / A protonic biotransducer controlling mitochondrial ATP synthesis. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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