A quasi-linear approach for microarray missing value imputation

Yu Cheng, Lan Wang, Jinglu Hu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Missing value imputation for microarray data is important for gene expression analysis algorithms, such as clustering, classification and network design. A number of algorithms have been proposed to solve this problem, but most of them are only limited in linear analysis methods, such as including the estimation in the linear combination of other no-missing-value genes. It may result from the fact that microarray data often comprises of huge size of genes with only a small number of observations, and nonlinear regression techniques are prone to overfitting. In this paper, a quasi-linear SVR model is proposed to improve the linear approaches, and it can be explained in a piecewise linear interpolation way. Two real datasets are tested and experimental results show that the quasi-linear approach for missing value imputation outperforms both the linear and nonlinear approaches.

Original languageEnglish
Title of host publicationNeural Information Processing - 18th International Conference, ICONIP 2011, Proceedings
Pages233-240
Number of pages8
EditionPART 1
DOIs
Publication statusPublished - 2011 Nov 28
Event18th International Conference on Neural Information Processing, ICONIP 2011 - Shanghai, China
Duration: 2011 Nov 132011 Nov 17

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume7062 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference18th International Conference on Neural Information Processing, ICONIP 2011
CountryChina
CityShanghai
Period11/11/1311/11/17

Keywords

  • SVR
  • microarray data
  • missing value imputation
  • quasi-linear

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Cheng, Y., Wang, L., & Hu, J. (2011). A quasi-linear approach for microarray missing value imputation. In Neural Information Processing - 18th International Conference, ICONIP 2011, Proceedings (PART 1 ed., pp. 233-240). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 7062 LNCS, No. PART 1). https://doi.org/10.1007/978-3-642-24955-6_28