A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions

Masateru Furusato, Tomohiro Shima, Yuma Kokuzawa, Kazuhiko Ito, Takashi Tanaka, Kiyotaka Iwasaki, Yi Qian, Mitsuo Umezu, ZhiKun Yan, Ling Zhu

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    A novel in vitro mock circulatory system, which enables to reproduce an inflow restriction, simulating blood volume pooling due to heart failure, was developed to evaluate a hydrodynamic performance of a pulsatile ventricular assist device (VAD) in practical conditions. The concept of this development was motivated by a difference of an inflow restriction between in vitro and in vivo environments. The major idea of this study is to reproduce an inflow restriction by using a centrifugal pump placed at an inflow side of a left ventricular model instead of a constant head reservoir in a conventional circuit. In the novel circuit, the maximum flow rate was obtained at lower systolic fraction as compared with a conventional circuit. This similar tendency by the novel one was observed in an acute animal experiment in sheep. This result suggests that a new mock circuit is effective to confirm a practical drive strategy of the VAD for various diseased conditions.

    Original languageEnglish
    Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Pages553-558
    Number of pages6
    Volume4689 LNBI
    Publication statusPublished - 2007
    Event2007 International Conference on Life System Modeling and Simulation, LSMS 2007 - Shanghai
    Duration: 2007 Sep 142007 Sep 17

    Publication series

    NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume4689 LNBI
    ISSN (Print)03029743
    ISSN (Electronic)16113349

    Other

    Other2007 International Conference on Life System Modeling and Simulation, LSMS 2007
    CityShanghai
    Period07/9/1407/9/17

    Fingerprint

    Heart-Assist Devices
    Hydrodynamics
    Cardiovascular System
    Reproduction
    Restriction
    Networks (circuits)
    Evaluate
    Blood Volume
    Sheep
    Heart Failure
    Head
    Centrifugal Pump
    Maximum Flow
    Pooling
    Centrifugal pumps
    Acute
    Flow Rate
    Blood
    Animals
    Flow rate

    ASJC Scopus subject areas

    • Computer Science(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Theoretical Computer Science

    Cite this

    Furusato, M., Shima, T., Kokuzawa, Y., Ito, K., Tanaka, T., Iwasaki, K., ... Zhu, L. (2007). A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4689 LNBI, pp. 553-558). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4689 LNBI).

    A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions. / Furusato, Masateru; Shima, Tomohiro; Kokuzawa, Yuma; Ito, Kazuhiko; Tanaka, Takashi; Iwasaki, Kiyotaka; Qian, Yi; Umezu, Mitsuo; Yan, ZhiKun; Zhu, Ling.

    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4689 LNBI 2007. p. 553-558 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4689 LNBI).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Furusato, M, Shima, T, Kokuzawa, Y, Ito, K, Tanaka, T, Iwasaki, K, Qian, Y, Umezu, M, Yan, Z & Zhu, L 2007, A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 4689 LNBI, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 4689 LNBI, pp. 553-558, 2007 International Conference on Life System Modeling and Simulation, LSMS 2007, Shanghai, 07/9/14.
    Furusato M, Shima T, Kokuzawa Y, Ito K, Tanaka T, Iwasaki K et al. A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4689 LNBI. 2007. p. 553-558. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
    Furusato, Masateru ; Shima, Tomohiro ; Kokuzawa, Yuma ; Ito, Kazuhiko ; Tanaka, Takashi ; Iwasaki, Kiyotaka ; Qian, Yi ; Umezu, Mitsuo ; Yan, ZhiKun ; Zhu, Ling. / A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4689 LNBI 2007. pp. 553-558 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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    AU - Ito, Kazuhiko

    AU - Tanaka, Takashi

    AU - Iwasaki, Kiyotaka

    AU - Qian, Yi

    AU - Umezu, Mitsuo

    AU - Yan, ZhiKun

    AU - Zhu, Ling

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