A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions

Masateru Furusato, Tomohiro Shima, Yuma Kokuzawa, Kazuhiko Ito, Takashi Tanaka, Kiyotaka Iwasaki, Yi Qian, Mitsuo Umezu, Zhi Kun Yan, Ling Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

A novel in vitro mock circulatory system, which enables to reproduce an inflow restriction, simulating blood volume pooling due to heart failure, was developed to evaluate a hydrodynamic performance of a pulsatile ventricular assist device (VAD) in practical conditions. The concept of this development was motivated by a difference of an inflow restriction between in vitro and in vivo environments. The major idea of this study is to reproduce an inflow restriction by using a centrifugal pump placed at an inflow side of a left ventricular model instead of a constant head reservoir in a conventional circuit. In the novel circuit, the maximum flow rate was obtained at lower systolic fraction as compared with a conventional circuit. This similar tendency by the novel one was observed in an acute animal experiment in sheep. This result suggests that a new mock circuit is effective to confirm a practical drive strategy of the VAD for various diseased conditions.

Original languageEnglish
Title of host publicationLife System Modeling and Simulation - International Conference, LSMS 2007, Proceedings
Pages553-558
Number of pages6
Publication statusPublished - 2007 Dec 1
Event2007 International Conference on Life System Modeling and Simulation, LSMS 2007 - Shanghai, China
Duration: 2007 Sep 142007 Sep 17

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4689 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference2007 International Conference on Life System Modeling and Simulation, LSMS 2007
CountryChina
CityShanghai
Period07/9/1407/9/17

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Fingerprint Dive into the research topics of 'A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions'. Together they form a unique fingerprint.

Cite this