Abstract
The ORL1 receptor (nociceptin receptor), the fourth member of the opioid receptor family, is widely distributed throughout the central nervous system and mediates diverse physiological functions including pain, emotion, learning and memory. Nociceptin receptors are densely expressed in the suprachiasmatic nucleus, the principal pacemaker of circadian rhythms, and nociceptin inhibits light-induced phase advances (Allen et al, 1999); however, nociceptin's role in nonphotic entrainment has not been described. We used a small-molecule nociceptin receptor agonist capable of crossing the brain blood-brain barrier, and demonstrated that nociceptin acts as a nonphotic zeitgeiber. In this review, we describe a role for nociceptin in the biological clock and discuss the possibility of developing nociceptin receptor agonists for treatment of circadian rhythm disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 203-211 |
| Number of pages | 9 |
| Journal | Japanese Journal of Neuropsychopharmacology |
| Volume | 25 |
| Issue number | 5 |
| Publication status | Published - 2005 Oct |
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Keywords
- Biological clock
- Circadian rhythm
- Nociceptin
- Suprachiasmatic nucleus
ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
A role of nociceptin in the entrainment mechanism of the biological clock. / Teshima, Koji; Shibata, Shigenobu.
In: Japanese Journal of Neuropsychopharmacology, Vol. 25, No. 5, 10.2005, p. 203-211.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A role of nociceptin in the entrainment mechanism of the biological clock
AU - Teshima, Koji
AU - Shibata, Shigenobu
PY - 2005/10
Y1 - 2005/10
N2 - The ORL1 receptor (nociceptin receptor), the fourth member of the opioid receptor family, is widely distributed throughout the central nervous system and mediates diverse physiological functions including pain, emotion, learning and memory. Nociceptin receptors are densely expressed in the suprachiasmatic nucleus, the principal pacemaker of circadian rhythms, and nociceptin inhibits light-induced phase advances (Allen et al, 1999); however, nociceptin's role in nonphotic entrainment has not been described. We used a small-molecule nociceptin receptor agonist capable of crossing the brain blood-brain barrier, and demonstrated that nociceptin acts as a nonphotic zeitgeiber. In this review, we describe a role for nociceptin in the biological clock and discuss the possibility of developing nociceptin receptor agonists for treatment of circadian rhythm disorders.
AB - The ORL1 receptor (nociceptin receptor), the fourth member of the opioid receptor family, is widely distributed throughout the central nervous system and mediates diverse physiological functions including pain, emotion, learning and memory. Nociceptin receptors are densely expressed in the suprachiasmatic nucleus, the principal pacemaker of circadian rhythms, and nociceptin inhibits light-induced phase advances (Allen et al, 1999); however, nociceptin's role in nonphotic entrainment has not been described. We used a small-molecule nociceptin receptor agonist capable of crossing the brain blood-brain barrier, and demonstrated that nociceptin acts as a nonphotic zeitgeiber. In this review, we describe a role for nociceptin in the biological clock and discuss the possibility of developing nociceptin receptor agonists for treatment of circadian rhythm disorders.
KW - Biological clock
KW - Circadian rhythm
KW - Nociceptin
KW - Suprachiasmatic nucleus
UR - http://www.scopus.com/inward/record.url?scp=28444435805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28444435805&partnerID=8YFLogxK
M3 - Article
C2 - 16313096
AN - SCOPUS:28444435805
VL - 25
SP - 203
EP - 211
JO - Neuropsychopharmacology Reports
JF - Neuropsychopharmacology Reports
SN - 1340-2544
IS - 5
ER -