A rotaxane-like complex with controlled-release characteristics

Sheng Hsien Chiu, Stuart J. Rowan, Stuart J. Cantrill, Peter T. Glink, Robin L. Garrell, J. Fraser Stoddart

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(matrix presented) A rotaxane-like complex, based on a dumbbell-shaped component containing an NH2+ recognition site for a [25]crown-8 ring component and a slippage stopper in the form of a p-(tert-butyl)phenyl group, has been synthesized by a "threading-followed-by-stoppering" approach. The half-life for dissociation of this complex, which is very sensitive to its environment, can be varied from minutes to months by changing the temperature and the polarity of the solvent.

Original languageEnglish
Pages (from-to)3631-3634
Number of pages4
JournalOrganic Letters
Issue number23
Publication statusPublished - 2000 Nov 16
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Chiu, S. H., Rowan, S. J., Cantrill, S. J., Glink, P. T., Garrell, R. L., & Stoddart, J. F. (2000). A rotaxane-like complex with controlled-release characteristics. Organic Letters, 2(23), 3631-3634.