A statistical theory of excitable membranes. Nonlinear force-flux relation and fluctuation

Yoji Aizawa, Yonosuke Kobatake

    Research output: Contribution to journalArticle

    Abstract

    A statistical theory of an excitable membrane is proposed under the assumptions that the membrane is composed of an ensemble of a number of active patches, and that the flip-flop transition of an active patch is governed by the dissipative interaction caused by an electric eddy current. By the method of expanding the master equation in the system size together with the Gaussian approximation, the time course of an excitation and the steady N-shaped relation between current and voltage are derived from the ensemble theory of open systems. The fluctuation of electric current under a fixed voltage becomes anomalously large in the marginal state at the threshold potential. The fluctuation associated with an action potential increases sharply at the jump-up transition, but it is not so large at the flip-back catastrophe. The fluctuation-dissipation relation at the steady state of the membrane system is discussed on the basis of a variational principle.

    Original languageEnglish
    Pages (from-to)129-139
    Number of pages11
    JournalJournal of Statistical Physics
    Volume15
    Issue number2
    DOIs
    Publication statusPublished - 1976 Aug

    Keywords

    • action potential
    • ensemble theory
    • Excitable membrane
    • fluctuation-dissipation relation
    • N-shaped I-V relation
    • Onsager principle
    • open system
    • system-size expansion

    ASJC Scopus subject areas

    • Statistical and Nonlinear Physics
    • Physics and Astronomy(all)
    • Mathematical Physics

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