A step forward for the undulation pump total artificial heart

Yusuke Abe, Tsuneo Chinzei, Takashi Isoyama, Toshiya Ono, Shuichi Mochizuki, Itsuro Saito, Kiyotaka Iwasaki, Mitsuhiko Ishimaru, Atsushi Baba, Akimasa Kouno, Toshinaga Ozeki, Takahiro Tohyama, Kazunori Baba, Kou Imachi

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    In the University of Tokyo, various types of total artificial heart (TAH) have been studied. Based on the experiences of TAH research, the development of the undulation pump total artificial heart (UPTAH) started in 1994. The undulation pump is a small-size, continuous-flow, displacement-type blood pump, and the UPTAH is a unique implantable total artificial heart that uses the undulation pump. To date, three models of UPTAH have been developed. The first model, UPTAH1, was developed to investigate the possibility of reducing the size of the device so it could be implanted in small adults, such as Japanese patients, in 1994. The second model, UPTAH2, which was the prototype of the animal experimental model, was developed in 1996 to investigate the possibility of survival with the UPTAH. The third model, UPTAH3, which is the present model, was developed in 1998 to enable long-term survival in animal experiments and to investigate the pathophysiology of the UPTAH. From July 1996 to October 1999, 22 implantations of UPTAH2 or UPTAH3 were performed in goats. In spite of the limitation of their small chest cavity, the UPTAH could be implanted into the chest of all goats. Using UPTAH3, survival of 31 days could be obtained. The research and development of UPTAH are ongoing.

    Original languageEnglish
    Pages (from-to)70-74
    Number of pages5
    JournalJournal of Artificial Organs
    Volume3
    Issue number2
    Publication statusPublished - 2000

    Fingerprint

    Artificial heart
    Artificial Heart
    Pumps
    Goats
    Survival
    Animals
    Thorax
    Tokyo
    Research
    Blood
    Animal Models

    Keywords

    • Animal experiment
    • Artificial heart
    • Implantable total artificial heart
    • Undulation pump

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Abe, Y., Chinzei, T., Isoyama, T., Ono, T., Mochizuki, S., Saito, I., ... Imachi, K. (2000). A step forward for the undulation pump total artificial heart. Journal of Artificial Organs, 3(2), 70-74.

    A step forward for the undulation pump total artificial heart. / Abe, Yusuke; Chinzei, Tsuneo; Isoyama, Takashi; Ono, Toshiya; Mochizuki, Shuichi; Saito, Itsuro; Iwasaki, Kiyotaka; Ishimaru, Mitsuhiko; Baba, Atsushi; Kouno, Akimasa; Ozeki, Toshinaga; Tohyama, Takahiro; Baba, Kazunori; Imachi, Kou.

    In: Journal of Artificial Organs, Vol. 3, No. 2, 2000, p. 70-74.

    Research output: Contribution to journalArticle

    Abe, Y, Chinzei, T, Isoyama, T, Ono, T, Mochizuki, S, Saito, I, Iwasaki, K, Ishimaru, M, Baba, A, Kouno, A, Ozeki, T, Tohyama, T, Baba, K & Imachi, K 2000, 'A step forward for the undulation pump total artificial heart', Journal of Artificial Organs, vol. 3, no. 2, pp. 70-74.
    Abe Y, Chinzei T, Isoyama T, Ono T, Mochizuki S, Saito I et al. A step forward for the undulation pump total artificial heart. Journal of Artificial Organs. 2000;3(2):70-74.
    Abe, Yusuke ; Chinzei, Tsuneo ; Isoyama, Takashi ; Ono, Toshiya ; Mochizuki, Shuichi ; Saito, Itsuro ; Iwasaki, Kiyotaka ; Ishimaru, Mitsuhiko ; Baba, Atsushi ; Kouno, Akimasa ; Ozeki, Toshinaga ; Tohyama, Takahiro ; Baba, Kazunori ; Imachi, Kou. / A step forward for the undulation pump total artificial heart. In: Journal of Artificial Organs. 2000 ; Vol. 3, No. 2. pp. 70-74.
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