A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex

Ryan Remedios, Dhananjay Huilgol, Bhaskar Saha, Padmanabhan Hari, Lahar Bhatnagar, Thomas Kowalczyk, Robert F. Hevner, Yoko Suda, Shinichi Aizawa, Toshio Ohshima, Anastassia Stoykova, Shubha Tole

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Abstract

The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link between the amygdala and the neocortex.

Original languageEnglish
Pages (from-to)1141-1150
Number of pages10
JournalNature Neuroscience
Volume10
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

ASJC Scopus subject areas

  • Neuroscience(all)

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    Remedios, R., Huilgol, D., Saha, B., Hari, P., Bhatnagar, L., Kowalczyk, T., Hevner, R. F., Suda, Y., Aizawa, S., Ohshima, T., Stoykova, A., & Tole, S. (2007). A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nature Neuroscience, 10(9), 1141-1150. https://doi.org/10.1038/nn1955