A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex

Ryan Remedios, Dhananjay Huilgol, Bhaskar Saha, Padmanabhan Hari, Lahar Bhatnagar, Thomas Kowalczyk, Robert F. Hevner, Yoko Suda, Shinichi Aizawa, Toshio Ohshima, Anastassia Stoykova, Shubha Tole

    Research output: Contribution to journalArticle

    69 Citations (Scopus)

    Abstract

    The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link between the amygdala and the neocortex.

    Original languageEnglish
    Pages (from-to)1141-1150
    Number of pages10
    JournalNature Neuroscience
    Volume10
    Issue number9
    DOIs
    Publication statusPublished - 2007 Sep

    Fingerprint

    Telencephalon
    Neocortex
    Amygdala
    Electroporation
    Neuroglia
    Cues
    Transcription Factors

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Remedios, R., Huilgol, D., Saha, B., Hari, P., Bhatnagar, L., Kowalczyk, T., ... Tole, S. (2007). A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nature Neuroscience, 10(9), 1141-1150. https://doi.org/10.1038/nn1955

    A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. / Remedios, Ryan; Huilgol, Dhananjay; Saha, Bhaskar; Hari, Padmanabhan; Bhatnagar, Lahar; Kowalczyk, Thomas; Hevner, Robert F.; Suda, Yoko; Aizawa, Shinichi; Ohshima, Toshio; Stoykova, Anastassia; Tole, Shubha.

    In: Nature Neuroscience, Vol. 10, No. 9, 09.2007, p. 1141-1150.

    Research output: Contribution to journalArticle

    Remedios, R, Huilgol, D, Saha, B, Hari, P, Bhatnagar, L, Kowalczyk, T, Hevner, RF, Suda, Y, Aizawa, S, Ohshima, T, Stoykova, A & Tole, S 2007, 'A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex', Nature Neuroscience, vol. 10, no. 9, pp. 1141-1150. https://doi.org/10.1038/nn1955
    Remedios, Ryan ; Huilgol, Dhananjay ; Saha, Bhaskar ; Hari, Padmanabhan ; Bhatnagar, Lahar ; Kowalczyk, Thomas ; Hevner, Robert F. ; Suda, Yoko ; Aizawa, Shinichi ; Ohshima, Toshio ; Stoykova, Anastassia ; Tole, Shubha. / A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. In: Nature Neuroscience. 2007 ; Vol. 10, No. 9. pp. 1141-1150.
    @article{37a07a1fbea24c6ea6e10da92498c15f,
    title = "A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex",
    abstract = "The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link between the amygdala and the neocortex.",
    author = "Ryan Remedios and Dhananjay Huilgol and Bhaskar Saha and Padmanabhan Hari and Lahar Bhatnagar and Thomas Kowalczyk and Hevner, {Robert F.} and Yoko Suda and Shinichi Aizawa and Toshio Ohshima and Anastassia Stoykova and Shubha Tole",
    year = "2007",
    month = "9",
    doi = "10.1038/nn1955",
    language = "English",
    volume = "10",
    pages = "1141--1150",
    journal = "Nature Neuroscience",
    issn = "1097-6256",
    publisher = "Nature Publishing Group",
    number = "9",

    }

    TY - JOUR

    T1 - A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex

    AU - Remedios, Ryan

    AU - Huilgol, Dhananjay

    AU - Saha, Bhaskar

    AU - Hari, Padmanabhan

    AU - Bhatnagar, Lahar

    AU - Kowalczyk, Thomas

    AU - Hevner, Robert F.

    AU - Suda, Yoko

    AU - Aizawa, Shinichi

    AU - Ohshima, Toshio

    AU - Stoykova, Anastassia

    AU - Tole, Shubha

    PY - 2007/9

    Y1 - 2007/9

    N2 - The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link between the amygdala and the neocortex.

    AB - The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link between the amygdala and the neocortex.

    UR - http://www.scopus.com/inward/record.url?scp=34548314071&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=34548314071&partnerID=8YFLogxK

    U2 - 10.1038/nn1955

    DO - 10.1038/nn1955

    M3 - Article

    VL - 10

    SP - 1141

    EP - 1150

    JO - Nature Neuroscience

    JF - Nature Neuroscience

    SN - 1097-6256

    IS - 9

    ER -