A study of magnetic drug delivery system using bulk high temperature superconducting magnet

Shigehiro Nishijima, Shin Ichi Takeda, Fumihito Mishima, Yasuhiko Tabata, Masaya Yamamoto, Jun Ichiro Joh, Hiroshi Iseki, Yoshihiro Muragaki, Akira Sasaki, Jun Kubota, Norihide Saho

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    31 Citations (Scopus)

    Abstract

    A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.

    Original languageEnglish
    Article number4517321
    Pages (from-to)874-877
    Number of pages4
    JournalIEEE Transactions on Applied Superconductivity
    Volume18
    Issue number2
    DOIs
    Publication statusPublished - 2008 Jun

    Keywords

    • Bulk high temperature superconductor
    • Magnetic drug delivery system
    • Magnetic seeded drug
    • Nano-sized particle
    • Navigation of drag

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Electrical and Electronic Engineering

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  • Cite this

    Nishijima, S., Takeda, S. I., Mishima, F., Tabata, Y., Yamamoto, M., Joh, J. I., Iseki, H., Muragaki, Y., Sasaki, A., Kubota, J., & Saho, N. (2008). A study of magnetic drug delivery system using bulk high temperature superconducting magnet. IEEE Transactions on Applied Superconductivity, 18(2), 874-877. [4517321]. https://doi.org/10.1109/TASC.2008.921967