A TEMPO-conjugated fluorescent probe for monitoring mitochondrial redox reactions

Shota Hirosawa, Satoshi Arai, Shinji Takeoka

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We report a mitochondrial targeted redox probe (MitoRP) that comprises a nitroxide radical (TEMPO) moiety and coumarin 343. Using isolated mitochondria in the presence/absence of substrates and inhibitors of oxidative phosphorylation, we demonstrated that MitoRP is a useful probe to monitor the electron flow associated with complex I.

Original languageEnglish
Pages (from-to)4845-4847
Number of pages3
JournalChemical Communications
Volume48
Issue number40
DOIs
Publication statusPublished - 2012 Apr 23

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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