A theory on auto-oscillation and contraction in striated muscle

Katsuhiko Sato, Masako Ohtaki, Yuta Shimamoto, Shin'ichi Ishiwata

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    It is widely accepted that muscle cells take either force-generating or relaxing state in an all-or-none fashion through the so-called excitation-contraction coupling. On the other hand, the membrane-less contractile apparatus takes the third state, i.e., the auto-oscillation (SPOC) state, at the activation level that is intermediate between full activation and relaxation. Here, to explain the dynamics of all three states of muscle, we construct a novel theoretical model based on the balance of forces not only parallel but also perpendicular to the long axis of myofibrils, taking into account the experimental fact that the spacing of myofilament lattice changes with sarcomere length and upon contraction. This theory presents a phase diagram composed of several states of the contractile apparatus and explains the dynamic behavior of SPOC, e.g., periodical changes in sarcomere length with the saw-tooth waveform. The appropriate selection of the constant of the molecular friction due to the cross-bridge formation can explain the difference in the SPOC periods observed under various activating conditions and in different muscle types, i.e., skeletal and cardiac. The theory also predicts the existence of a weak oscillation state at the boundary between SPOC and relaxation regions in the phase diagram. Thus, the present theory comprehensively explains the characteristics of auto-oscillation and contraction in the contractile system of striated muscle.

    Original languageEnglish
    Pages (from-to)199-207
    Number of pages9
    JournalProgress in Biophysics and Molecular Biology
    Volume105
    Issue number3
    DOIs
    Publication statusPublished - 2011 May

    Fingerprint

    Sarcomeres
    Striated Muscle
    Myofibrils
    Excitation Contraction Coupling
    Friction
    Muscle Cells
    Myocardium
    Tooth
    Skeletal Muscle
    Theoretical Models
    Muscles
    Membranes

    Keywords

    • Limit cycle
    • Sarcomere
    • SPOC
    • Thick filament
    • Thin filament
    • Z-line

    ASJC Scopus subject areas

    • Molecular Biology
    • Biophysics

    Cite this

    A theory on auto-oscillation and contraction in striated muscle. / Sato, Katsuhiko; Ohtaki, Masako; Shimamoto, Yuta; Ishiwata, Shin'ichi.

    In: Progress in Biophysics and Molecular Biology, Vol. 105, No. 3, 05.2011, p. 199-207.

    Research output: Contribution to journalArticle

    Sato, Katsuhiko ; Ohtaki, Masako ; Shimamoto, Yuta ; Ishiwata, Shin'ichi. / A theory on auto-oscillation and contraction in striated muscle. In: Progress in Biophysics and Molecular Biology. 2011 ; Vol. 105, No. 3. pp. 199-207.
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