Absolute configuration of iminimycin B, a new indolizidine alkaloid, from Streptomyces griseus OS-3601

Takuji Nakashima*, Rei Miyano, Hirotaka Matsuo, Masato Iwatsuki, Tatsuya Shirahata, Yoshinori Kobayashi, Kazuro Shiomi, George A. Petersson, Yōko Takahashi, Satoshi Ōmura

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Iminimycin B, a novel indolizine alkaloid featuring a rare pyridinium, was isolated from the cultured broth of a streptomycin-producing strain, Streptomyces griseus OS-3601, through a physicochemical screening method. Its structure was elucidated on the basis of mass and NMR analyses. Stereochemical assignment of iminimycin B was archived by NMR studies, electronic circular dichroism (ECD) analysis, and advanced Marfey's method.

Original languageEnglish
Pages (from-to)3284-3286
Number of pages3
JournalTetrahedron Letters
Volume57
Issue number30
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Iminimycin
  • Indolizidine
  • Pyridinium
  • Streptomyces

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Absolute configuration of iminimycin B, a new indolizidine alkaloid, from Streptomyces griseus OS-3601'. Together they form a unique fingerprint.

Cite this