TY - JOUR
T1 - Absolute structure and anti-oxidative activity of chaetochiversin c isolated from fungal strain neocosmospora sp. Fki-7792 by physicochemical screening
AU - Matsuo, Hirotaka
AU - Hirose, Tomoyasu
AU - Mokudai, Takayuki
AU - Nonaka, Kenichi
AU - Niwano, Yoshimi
AU - Sunazuka, Toshiaki
AU - Takahashi, Yōko
AU - Ōmura, Satoshi
AU - Nakashima, Takuji
N1 - Funding Information:
This study was supported by funds from the Institute for Fermentation, Osaka (IFO), Japan. We are grateful for Dr. Kenichiro Nagai, School of Pharmacy, Kitasato University, for the MS measurements.
Publisher Copyright:
© 2020 Applied Microbiology, Molecular and Cellular Biosciences Research Foundation.
PY - 2020
Y1 - 2020
N2 - A new chaetochiversin analog, designated chaetochiversin C (1), was discovered from a cul-tured broth of fungal strain FKI-7792 by physico-chemical screening. This strain was identified as a member of genus Neocosmospora based on mor-phology and DNA barcoding. The partially relative configuration of 1 was determined by13C-NMR chemical shifts of the acetonide analog of 1. The absolute configuration was determined using an advanced Mosher’s method. Compound 1 was as-sessed for anti-tumor, anti-microbial, and anti-malarial activities, and its ability to scavenge or quench reactive oxygen species (ROS), such as superoxide anion radicals, hydroxy radicals and singlet oxygen (1O2 ). Compound 1 showed a quenching effect on1O2.
AB - A new chaetochiversin analog, designated chaetochiversin C (1), was discovered from a cul-tured broth of fungal strain FKI-7792 by physico-chemical screening. This strain was identified as a member of genus Neocosmospora based on mor-phology and DNA barcoding. The partially relative configuration of 1 was determined by13C-NMR chemical shifts of the acetonide analog of 1. The absolute configuration was determined using an advanced Mosher’s method. Compound 1 was as-sessed for anti-tumor, anti-microbial, and anti-malarial activities, and its ability to scavenge or quench reactive oxygen species (ROS), such as superoxide anion radicals, hydroxy radicals and singlet oxygen (1O2 ). Compound 1 showed a quenching effect on1O2.
KW - Absolute structure
KW - Antioxidant
KW - Chaetochiversin analog
KW - Neocosmospora
KW - Physico-chemical screening
UR - http://www.scopus.com/inward/record.url?scp=85090079840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090079840&partnerID=8YFLogxK
U2 - 10.2323/jgam.2019.06.001
DO - 10.2323/jgam.2019.06.001
M3 - Article
C2 - 31735764
AN - SCOPUS:85090079840
SN - 0022-1260
VL - 66
SP - 181
EP - 187
JO - Journal of General and Applied Microbiology
JF - Journal of General and Applied Microbiology
IS - 3
ER -