Actigraphy in patients with major depressive disorder undergoing repetitive transcranial magnetic stimulation an open label pilot study

Masaki Nishida, Senichiro Kikuchi, Koichi Nisijima, Shiro Suda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The effects of repetitive transcranial magnetic stimulation (rTMS) on physical activity and sleep patterns in individuals with major depressive disorder (MDD) remain unclear. Method: We examined the effects of rTMS treatment on the rest-activity cycle and sleep disturbances in MDD. In this open-label pilot study, 14 patients with medication-resistant MDD underwent 10 rTMS sessions over the bilateral dorsolateral prefrontal cortex. In addition to Hamilton Depression Rating Scale and Pittsburgh Sleep Quality Index scores, waist actigraphy was used to evaluate alterations in the rest-activity cycle over the course of rTMS treatments. Actigraphic data were evaluated at baseline and in the first (rTMS sessions 1-3), second (rTMS sessions 4-7), and third (rTMS sessions 8-10) sections. Results: Although Hamilton Depression Rating Scale and Pittsburgh Sleep Quality Index scores were significantly improved by rTMS, sleep variables assessed by actigraphy did not show significant changes. However, post hoc tests indicated a significant increase in mean steps per day between the baseline and first section time points (P = 0.014; t13 =-2.316). Conclusions: Our data indicated that a daytime physical activity response to rTMS occurred in early sessions, whereas subjective symptom improvements were consistent across all sessions. Future double-blind placebo-controlled studies assessing the effects of rTMS on the rest-activity cycle and sleep disturbances in MDD are warranted.

Original languageEnglish
Pages (from-to)36-42
Number of pages7
JournalJournal of ECT
Volume33
Issue number1
DOIs
Publication statusPublished - 2017
Externally publishedYes

Fingerprint

Actigraphy
Transcranial Magnetic Stimulation
Major Depressive Disorder
Sleep
Activity Cycles
Exercise
Depression
Prefrontal Cortex
Placebos

Keywords

  • Actigraphy
  • Major depressive disorder
  • Rest-activity cycle
  • RTMS
  • Sleep

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Psychiatry and Mental health

Cite this

Actigraphy in patients with major depressive disorder undergoing repetitive transcranial magnetic stimulation an open label pilot study. / Nishida, Masaki; Kikuchi, Senichiro; Nisijima, Koichi; Suda, Shiro.

In: Journal of ECT, Vol. 33, No. 1, 2017, p. 36-42.

Research output: Contribution to journalArticle

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