Actinomycins produced by streptomyces lichenis lcr6-01t and its antibacterial activity

Pawina Kanchanasin; Patcharin Saeng-In; Takuji Nakashima; Hirotaka Matsuo; Yōko Takahashi; Somboon Tanasupawat

Actinomycins produced by streptomyces lichenis lcr6-01^t and its antibacterial activity

Pawina Kanchanasin, Patcharin Saeng-In, Takuji Nakashima, Hirotaka Matsuo, Yōko Takahashi, Somboon Tanasupawat^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A new actinomycete species, Streptomyces lichenis LCR6-01^T was isolated from lichen collected in Chiang Rai province, Thailand. On the course of screening for antimicrobial activity, the culture broth of strain LCR6-01^T exhibited antibacterial activity against Bacillus subtilis ATCC 6633, Kocuria rhizophila ATCC 9341, Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 (inhibition zone 14.7 ± 0.6-23.0 ± 0.9 mm). The culture extracts analyzed by liquid chromatographyelectrospray ionization-mass spectrometry (LC-ESI-MS) and the physicochemical properties of secondary metabolites were searched in database. The antibacterial agents were detected as actinomycins which contained 3 analogs of Au7a, D, and D 43β.

Original language	English
Pages (from-to)	864-871
Number of pages	8
Journal	Chiang Mai Journal of Science
Volume	47
Issue number	5
Publication status	Published - 2020 Sept
Externally published	Yes

Keywords

Actinomycin
Antimicrobial activity
Mass spectrometry
Streptomyces lichenis

ASJC Scopus subject areas

Chemistry(all)
Mathematics(all)
Materials Science(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

Cite this

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title = "Actinomycins produced by streptomyces lichenis lcr6-01t and its antibacterial activity",

abstract = "A new actinomycete species, Streptomyces lichenis LCR6-01T was isolated from lichen collected in Chiang Rai province, Thailand. On the course of screening for antimicrobial activity, the culture broth of strain LCR6-01T exhibited antibacterial activity against Bacillus subtilis ATCC 6633, Kocuria rhizophila ATCC 9341, Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 (inhibition zone 14.7 ± 0.6-23.0 ± 0.9 mm). The culture extracts analyzed by liquid chromatographyelectrospray ionization-mass spectrometry (LC-ESI-MS) and the physicochemical properties of secondary metabolites were searched in database. The antibacterial agents were detected as actinomycins which contained 3 analogs of Au7a, D, and D 43β.",

keywords = "Actinomycin, Antimicrobial activity, Mass spectrometry, Streptomyces lichenis",

author = "Pawina Kanchanasin and Patcharin Saeng-In and Takuji Nakashima and Hirotaka Matsuo and Yōko Takahashi and Somboon Tanasupawat",

note = "Funding Information: This research was supported by the Grant for International Research Integration: Research Pyramid, Ratchadaphiseksomphot Endowment Fund (GCURP_58_01_33_01). We thank the Ratchadapiseksomphot Endowment Fund, Chulalongkorn University for a post-doctoral fellowship to P. K. Publisher Copyright: {\textcopyright} 2020, Chiang Mai University. All rights reserved.",

year = "2020",

month = sep,

language = "English",

volume = "47",

pages = "864--871",

journal = "Chiang Mai Journal of Science",

issn = "0125-2526",

publisher = "Chiang Mai University",

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T1 - Actinomycins produced by streptomyces lichenis lcr6-01t and its antibacterial activity

AU - Kanchanasin, Pawina

AU - Saeng-In, Patcharin

AU - Nakashima, Takuji

AU - Matsuo, Hirotaka

AU - Takahashi, Yōko

AU - Tanasupawat, Somboon

N1 - Funding Information: This research was supported by the Grant for International Research Integration: Research Pyramid, Ratchadaphiseksomphot Endowment Fund (GCURP_58_01_33_01). We thank the Ratchadapiseksomphot Endowment Fund, Chulalongkorn University for a post-doctoral fellowship to P. K. Publisher Copyright: © 2020, Chiang Mai University. All rights reserved.

PY - 2020/9

Y1 - 2020/9

N2 - A new actinomycete species, Streptomyces lichenis LCR6-01T was isolated from lichen collected in Chiang Rai province, Thailand. On the course of screening for antimicrobial activity, the culture broth of strain LCR6-01T exhibited antibacterial activity against Bacillus subtilis ATCC 6633, Kocuria rhizophila ATCC 9341, Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 (inhibition zone 14.7 ± 0.6-23.0 ± 0.9 mm). The culture extracts analyzed by liquid chromatographyelectrospray ionization-mass spectrometry (LC-ESI-MS) and the physicochemical properties of secondary metabolites were searched in database. The antibacterial agents were detected as actinomycins which contained 3 analogs of Au7a, D, and D 43β.

AB - A new actinomycete species, Streptomyces lichenis LCR6-01T was isolated from lichen collected in Chiang Rai province, Thailand. On the course of screening for antimicrobial activity, the culture broth of strain LCR6-01T exhibited antibacterial activity against Bacillus subtilis ATCC 6633, Kocuria rhizophila ATCC 9341, Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 (inhibition zone 14.7 ± 0.6-23.0 ± 0.9 mm). The culture extracts analyzed by liquid chromatographyelectrospray ionization-mass spectrometry (LC-ESI-MS) and the physicochemical properties of secondary metabolites were searched in database. The antibacterial agents were detected as actinomycins which contained 3 analogs of Au7a, D, and D 43β.

KW - Actinomycin

KW - Antimicrobial activity

KW - Mass spectrometry

KW - Streptomyces lichenis

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SN - 0125-2526

VL - 47

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JO - Chiang Mai Journal of Science

JF - Chiang Mai Journal of Science

IS - 5

ER -

Actinomycins produced by streptomyces lichenis lcr6-01^t and its antibacterial activity

Abstract

Keywords

ASJC Scopus subject areas

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