Active and precise control of microdroplet division using horizontal pneumatic valves in bifurcating microchannel

Dong Hyun Yoon, Junichi Ito, Tetsushi Sekiguchi, Shuichi Shoji

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This paper presents a microfluidic system for the active and precise control of microdroplet division in a micro device. Using two horizontal pneumatic valves formed at downstream of bifurcating microchannel, flow resistances of downstream channels were variably controlled. With the resistance control, volumetric ratio of downstream flows was changed and water-in-oil microdroplets were divided into two daughter droplets of different volume corresponding to the ratio. The microfluidic channels and pneumatic valves were fabricated by single-step soft lithography process of PDMS (polydimethylsiloxane) using SU-8 mold. A wide range control of the daughter droplets' volume ratio was achieved by the simple channel structure. Volumetric ratio between large and small daughter droplets are ranged from 1 to 70, and the smallest droplet volume of 14 pL was obtained. The proposed microfluidic device is applicable for precise and high throughput droplet based digital synthesis.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalMicromachines
Volume4
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • Bifurcating microchannel
  • Division
  • Horizontal pneumatic valve
  • Microdroplet
  • PDMS

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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