Activity of midbrain reticular formation and neocortex during the progression of human non-rapid eye movement sleep

Naofumi Kajimura, Makoto Uchiyama, Yutaka Takayama, Sunao Uchida, Takeshi Uema, Masaaki Kato, Masanori Sekimoto, Tsuyoshi Watanabe, Toru Nakajima, Satoru Horikoshi, Kenichi Ogawa, Masami Nishikawa, Masahiko Hiroki, Yoshihisa Kudo, Hiroshi Matsuda, Masako Okawa, Kiyohisa Takahashi

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

To clarify the neural correlates and brain activity during the progression of human non-rapid eye movement (NREM) sleep, we examined the absolute regional cerebral blood flow (rCBF) during light and deep NREM sleep and during wakefulness in normal humans using positron emission tomography with H2 15O. Relative changes in rCBF during light and deep NREM sleep in comparison to the rCBF during wakefulness were also analyzed. During light NREM sleep, the rCBF in the midbrain, in contrast to that in the pons and thalamic nuclei, did not decrease when compared to that during wakefulness, whereas rCBF decreased in the left medial frontal gyrus, left inferior frontal gyrus, and left inferior parietal gyrus of the neocortex. During deep NREM sleep, the rCBF in the midbrain tegmentum decreased, and there was a marked and bilateral decrease in the rCBF in all neocortical regions except for the perirolandic areas and the occipital lobe. There have been three groups of brain structures, each representing one type of deactivation during the progression of NREM sleep. The activity of the midbrain reticular formation is maintained during light NREM sleep and therefore represents a key distinguishing characteristic between light and deep NREM sleep. Selective deactivation of heteromodal association cortices, including those related to language, occurs with increasingly deep NREM sleep, which supports the recent theory that sleep is not a global, but it is a local process of the brain.

Original languageEnglish
Pages (from-to)10065-10073
Number of pages9
JournalJournal of Neuroscience
Volume19
Issue number22
Publication statusPublished - 1999 Nov 15
Externally publishedYes

Keywords

  • Ascending reticular activating system
  • Cerebral blood flow
  • Heteromodal association cortex
  • Midbrain reticular formation
  • NREM sleep
  • Positron emission tomography
  • Selective deactivation

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Kajimura, N., Uchiyama, M., Takayama, Y., Uchida, S., Uema, T., Kato, M., Sekimoto, M., Watanabe, T., Nakajima, T., Horikoshi, S., Ogawa, K., Nishikawa, M., Hiroki, M., Kudo, Y., Matsuda, H., Okawa, M., & Takahashi, K. (1999). Activity of midbrain reticular formation and neocortex during the progression of human non-rapid eye movement sleep. Journal of Neuroscience, 19(22), 10065-10073.