Activity of some atypical antidepressants on five models of muricide in rat

I. M.H. Al-Khatib; M. Fujiwara; S. Shibata; S. Ueki

Activity of some atypical antidepressants on five models of muricide in rat

I. M.H. Al-Khatib, M. Fujiwara, S. Shibata, S. Ueki

School of Advanced Science and Engineering

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Abstract

We examined the effects of atypical antidepressants; nomifensine (NOM), zimelidine (ZIM) and mianserin (MIAN) on muricide induced by olfactory bulbectomy (OB), lesions of raphe nuclei (Raphe) and nucleus accumbens (ACC), and Δ⁹-tetrahydrocannabinol (THC) administration, in comparison with that of (IMP). NOM selectively suppressed muricide induced by ACC lesion and THC administration; ZIM and IMP showed higher selectivity in suppressing muricide in all models studied while MIAN only in ACC lesioned rats. These results besides revealing that muricide of ACC rats was most prominently suppressed by antidepressants, also indicated the possible relationship between the causal factors of muricide and the mechanisms of action of some of the drugs used.

Original language	English
Pages (from-to)	79-85
Number of pages	7
Journal	Asia Pacific Journal of Pharmacology
Volume	1
Issue number	2
Publication status	Published - 1986 Jan 1

ASJC Scopus subject areas

Pharmacology

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Al-Khatib, I. M. H., Fujiwara, M., Shibata, S., & Ueki, S. (1986). Activity of some atypical antidepressants on five models of muricide in rat. Asia Pacific Journal of Pharmacology, 1(2), 79-85.

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