Abstract
We examined the effects of atypical antidepressants; nomifensine (NOM), zimelidine (ZIM) and mianserin (MIAN) on muricide induced by olfactory bulbectomy (OB), lesions of raphe nuclei (Raphe) and nucleus accumbens (ACC), and Δ9-tetrahydrocannabinol (THC) administration, in comparison with that of (IMP). NOM selectively suppressed muricide induced by ACC lesion and THC administration; ZIM and IMP showed higher selectivity in suppressing muricide in all models studied while MIAN only in ACC lesioned rats. These results besides revealing that muricide of ACC rats was most prominently suppressed by antidepressants, also indicated the possible relationship between the causal factors of muricide and the mechanisms of action of some of the drugs used.
| Original language | English |
|---|---|
| Journal | Asia Pacific Journal of Pharmacology |
| Volume | 1 |
| Issue number | 2 |
| Publication status | Published - 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
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Activity of some atypical antidepressants on five models of muricide in rat. / Al-Khatib, I. M H; Fujiwara, M.; Shibata, Shigenobu; Ueki, S.
In: Asia Pacific Journal of Pharmacology, Vol. 1, No. 2, 1986.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Activity of some atypical antidepressants on five models of muricide in rat
AU - Al-Khatib, I. M H
AU - Fujiwara, M.
AU - Shibata, Shigenobu
AU - Ueki, S.
PY - 1986
Y1 - 1986
N2 - We examined the effects of atypical antidepressants; nomifensine (NOM), zimelidine (ZIM) and mianserin (MIAN) on muricide induced by olfactory bulbectomy (OB), lesions of raphe nuclei (Raphe) and nucleus accumbens (ACC), and Δ9-tetrahydrocannabinol (THC) administration, in comparison with that of (IMP). NOM selectively suppressed muricide induced by ACC lesion and THC administration; ZIM and IMP showed higher selectivity in suppressing muricide in all models studied while MIAN only in ACC lesioned rats. These results besides revealing that muricide of ACC rats was most prominently suppressed by antidepressants, also indicated the possible relationship between the causal factors of muricide and the mechanisms of action of some of the drugs used.
AB - We examined the effects of atypical antidepressants; nomifensine (NOM), zimelidine (ZIM) and mianserin (MIAN) on muricide induced by olfactory bulbectomy (OB), lesions of raphe nuclei (Raphe) and nucleus accumbens (ACC), and Δ9-tetrahydrocannabinol (THC) administration, in comparison with that of (IMP). NOM selectively suppressed muricide induced by ACC lesion and THC administration; ZIM and IMP showed higher selectivity in suppressing muricide in all models studied while MIAN only in ACC lesioned rats. These results besides revealing that muricide of ACC rats was most prominently suppressed by antidepressants, also indicated the possible relationship between the causal factors of muricide and the mechanisms of action of some of the drugs used.
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UR - http://www.scopus.com/inward/citedby.url?scp=17344395243&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:17344395243
VL - 1
JO - Asia Pacific Journal of Pharmacology
JF - Asia Pacific Journal of Pharmacology
SN - 0217-9687
IS - 2
ER -