Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men

David R. Broom, Masashi Miyashita, Lucy K. Wasse, Richard Pulsford, James A. King, Alice E. Thackray, David J. Stensel

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Acute exercise transiently suppresses the orexigenic gut hormone acylated ghrelin, but the extent to which exercise intensity and duration determine this response is not fully understood. The effects of manipulating exercise intensity and duration on acylated ghrelin concentrations and hunger were examined in two experiments. In experiment one, nine healthy males completed three, 4-h conditions (control, moderate-intensity running (MOD) and vigorous-intensity running (VIG)), with an energy expenditure of ~2.5 MJ induced in both MOD (55-min running at 52% peak oxygen uptake (VO2peak)) and VIG (36-min running at 75% VO2peak). In experiment two, nine healthy males completed three, 9-h conditions (control, 45-min running (EX45) and 90-min running (EX90)). Exercise was performed at 70% VO2peak. In both experiments, participants consumed standardised meals, and acylated ghrelin concentrations and hunger were quantified at predetermined intervals. In experiment one, delta acylated ghrelin concentrations were lower than control in MOD (ES = 0.44, P = 0.01) and VIG (ES = 0.98, P < 0.001); VIG was lower than MOD (ES = 0.54, P = 0.003). Hunger ratings were similar across the conditions (P = 0.35). In experiment two, delta acylated ghrelin concentrations were lower than control in EX45 (ES = 0.77, P<0.001) and EX90 (ES = 0.68, P<0.001); EX45 and EX90 were similar (ES = 0.09, P = 0.55). Hunger ratings were lower than control in EX45 (ES = 0.20, P = 0.01) and EX90 (ES = 0.27, P = 0.001); EX45 and EX90 were similar (ES = 0.07, P = 0.34). Hunger and delta acylated ghrelin concentrations remained suppressed at 1.5 h in EX90 but not EX45. In conclusion, exercise intensity, and to a lesser extent duration, are determinants of the acylated ghrelin response to acute exercise.

Original languageEnglish
Pages (from-to)411-422
Number of pages12
JournalJournal of Endocrinology
Volume232
Issue number3
DOIs
Publication statusPublished - 2017

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Ghrelin
Hunger
Running
Exercise
Energy Metabolism
Meals

Keywords

  • Appetite
  • Energy balance
  • Exercise characteristics
  • Exercise-induced anorexia
  • Gut peptides

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Broom, D. R., Miyashita, M., Wasse, L. K., Pulsford, R., King, J. A., Thackray, A. E., & Stensel, D. J. (2017). Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men. Journal of Endocrinology, 232(3), 411-422. https://doi.org/10.1530/JOE-16-0561

Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men. / Broom, David R.; Miyashita, Masashi; Wasse, Lucy K.; Pulsford, Richard; King, James A.; Thackray, Alice E.; Stensel, David J.

In: Journal of Endocrinology, Vol. 232, No. 3, 2017, p. 411-422.

Research output: Contribution to journalArticle

Broom, DR, Miyashita, M, Wasse, LK, Pulsford, R, King, JA, Thackray, AE & Stensel, DJ 2017, 'Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men', Journal of Endocrinology, vol. 232, no. 3, pp. 411-422. https://doi.org/10.1530/JOE-16-0561
Broom, David R. ; Miyashita, Masashi ; Wasse, Lucy K. ; Pulsford, Richard ; King, James A. ; Thackray, Alice E. ; Stensel, David J. / Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men. In: Journal of Endocrinology. 2017 ; Vol. 232, No. 3. pp. 411-422.
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abstract = "Acute exercise transiently suppresses the orexigenic gut hormone acylated ghrelin, but the extent to which exercise intensity and duration determine this response is not fully understood. The effects of manipulating exercise intensity and duration on acylated ghrelin concentrations and hunger were examined in two experiments. In experiment one, nine healthy males completed three, 4-h conditions (control, moderate-intensity running (MOD) and vigorous-intensity running (VIG)), with an energy expenditure of ~2.5 MJ induced in both MOD (55-min running at 52{\%} peak oxygen uptake (VO2peak)) and VIG (36-min running at 75{\%} VO2peak). In experiment two, nine healthy males completed three, 9-h conditions (control, 45-min running (EX45) and 90-min running (EX90)). Exercise was performed at 70{\%} VO2peak. In both experiments, participants consumed standardised meals, and acylated ghrelin concentrations and hunger were quantified at predetermined intervals. In experiment one, delta acylated ghrelin concentrations were lower than control in MOD (ES = 0.44, P = 0.01) and VIG (ES = 0.98, P < 0.001); VIG was lower than MOD (ES = 0.54, P = 0.003). Hunger ratings were similar across the conditions (P = 0.35). In experiment two, delta acylated ghrelin concentrations were lower than control in EX45 (ES = 0.77, P<0.001) and EX90 (ES = 0.68, P<0.001); EX45 and EX90 were similar (ES = 0.09, P = 0.55). Hunger ratings were lower than control in EX45 (ES = 0.20, P = 0.01) and EX90 (ES = 0.27, P = 0.001); EX45 and EX90 were similar (ES = 0.07, P = 0.34). Hunger and delta acylated ghrelin concentrations remained suppressed at 1.5 h in EX90 but not EX45. In conclusion, exercise intensity, and to a lesser extent duration, are determinants of the acylated ghrelin response to acute exercise.",
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