Acute Effect of High-Intensity Eccentric Exercise on Vascular Endothelial Function in Young Men

Youngju Choi, Nobuhiko Akazawa, Asako Zempo-Miyaki, Song Gyu Ra, Hitoshi Shiraki, Ryuichi Ajisaka, Seiji Maeda

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Choi, Y, Akazawa, N, Zempo-Miyaki, A, Ra, S-G, Shiraki, H, Ajisaka, R, and Maeda, S. Acute effect of high-intensity eccentric exercise on vascular endothelial function in young men. J Strength Cond Res 30(8): 2279-2285, 2016 - Increased central arterial stiffness is as an independent risk factor for cardiovascular disease. Evidence regarding the effects of high-intensity resistance exercise on vascular endothelial function and central arterial stiffness is conflicting. The purpose of this study was to examine the effects of acute high-intensity eccentric exercise on vascular endothelial function and central arterial stiffness. We evaluated the acute changes in endothelium-dependent flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and arterial stiffness after high-intensity eccentric exercise. Seven healthy, sedentary men (age, 24 ± 1 year) performed maximal eccentric elbow flexor exercise using their nondominant arm. Before and 45 minutes after eccentric exercise, carotid arterial compliance and brachial artery FMD and L-FMC in the nonexercised arm were measured. Carotid arterial compliance was significantly decreased, and β-stiffness index significantly increased after eccentric exercise. Brachial FMD was significantly reduced after eccentric exercise, whereas there was no significant difference in brachial L-FMC before and after eccentric exercise. A positive correlation was detected between change in arterial compliance and change in FMD (r 0.779; p ≤ 0.05), and a negative correlation was detected between change in β-stiffness index and change in FMD (r -0.891; p < 0.01) with eccentric exercise. In this study, acute high-intensity eccentric exercise increased central arterial stiffness; this increase was accompanied by a decrease in endothelial function caused by reduced endothelium-dependent vasodilation but not by a change in endothelium-dependent vasoconstriction.

Original languageEnglish
Pages (from-to)2279-2285
Number of pages7
JournalJournal of strength and conditioning research
Volume30
Issue number8
DOIs
Publication statusPublished - 2016 Aug 1
Externally publishedYes

Keywords

  • flow-mediated dilation
  • high-intensity resistance exercise
  • low-flow-mediated constriction
  • vasoconstriction
  • vasodilation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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