Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice

Yutaka Matsumoto, Sihui Ma, Takaki Tominaga, Keiko Yokoyama, Kanae Kitatani, Kazumasa Horikawa, Katsuhiko Suzuki

Research output: Contribution to journalArticle

Abstract

Background and objectives: Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. Materials and Methods: Eight-week-old male hairless mice were randomly divided into naïve control and treatment groups. In the treatment group, mice were topically administered 4 μL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Thereafter, serum biochemical parameters were assayed, and gene expression was analyzed in various tissues via a real-time polymerase chain reaction. Results: Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil (p < 0.05). Atgl was significantly upregulated in the liver (p < 0.05), and Atgl upregulation in the liver was positively correlated with serum NEFA levels (r = 0.592, p < 0.05). Furthermore, a trend of decreasing fatty acid trafficking-related gene (FABPpm, FATP-1, FATP-3, and FATP-4) expression in the skin after topical application of jojoba oil (p = 0.067, 0.074, 0.076, and 0.082, respectively) was observed. Conclusions: Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil. The mechanisms of elevated serum NEFA levels might be related to both enhanced lipolysis in the liver and reduced fatty acid trafficking in the skin.

Original languageEnglish
JournalMedicina (Kaunas, Lithuania)
Volume55
Issue number9
DOIs
Publication statusPublished - 2019 Sep 15

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Cutaneous Administration
Lipid Metabolism
Fatty Acids
Serum
Liver
Oils
Aromatherapy
Hairless Mouse
Skin
Euthanasia
Lipolysis
Volatile Oils
Complementary Therapies
jojoba wax
Real-Time Polymerase Chain Reaction
Up-Regulation
Body Weight
Gene Expression
Control Groups
Therapeutics

Keywords

  • aromatherapy
  • fatty acid
  • jojoba oil
  • lipid metabolism
  • non-esterified fatty acids (NEFA)
  • transdermal absorption

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice. / Matsumoto, Yutaka; Ma, Sihui; Tominaga, Takaki; Yokoyama, Keiko; Kitatani, Kanae; Horikawa, Kazumasa; Suzuki, Katsuhiko.

In: Medicina (Kaunas, Lithuania), Vol. 55, No. 9, 15.09.2019.

Research output: Contribution to journalArticle

Matsumoto, Yutaka ; Ma, Sihui ; Tominaga, Takaki ; Yokoyama, Keiko ; Kitatani, Kanae ; Horikawa, Kazumasa ; Suzuki, Katsuhiko. / Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice. In: Medicina (Kaunas, Lithuania). 2019 ; Vol. 55, No. 9.
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AU - Suzuki, Katsuhiko

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AB - Background and objectives: Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. Materials and Methods: Eight-week-old male hairless mice were randomly divided into naïve control and treatment groups. In the treatment group, mice were topically administered 4 μL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Thereafter, serum biochemical parameters were assayed, and gene expression was analyzed in various tissues via a real-time polymerase chain reaction. Results: Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil (p < 0.05). Atgl was significantly upregulated in the liver (p < 0.05), and Atgl upregulation in the liver was positively correlated with serum NEFA levels (r = 0.592, p < 0.05). Furthermore, a trend of decreasing fatty acid trafficking-related gene (FABPpm, FATP-1, FATP-3, and FATP-4) expression in the skin after topical application of jojoba oil (p = 0.067, 0.074, 0.076, and 0.082, respectively) was observed. Conclusions: Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil. The mechanisms of elevated serum NEFA levels might be related to both enhanced lipolysis in the liver and reduced fatty acid trafficking in the skin.

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