Acute endurance exercise lowers serum fibroblast growth factor 21 levels in Japanese men

Hirokazu Taniguchi, Kumpei Tanisawa, Xiaomin Sun, Mitsuru Higuchi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: The independent effects of acute endurance exercise on FGF21 metabolism are poorly understood. Therefore, the purpose of this study was to determine whether acute endurance exercise modulates serum postprandial FGF21 levels in an age-dependent manner. Design: Exercise intervention trial. Patients: Twenty-eight subjects participated in the experiment, of whom 13 were excluded mainly because of a serum FGF21 level below the limit of detection. Thus, data from seven young (age: 18–22 years) and eight elderly male subjects (age: 62–69 years) were analysed. Measurements: Participants were asked to perform a cycling exercise for 30 min at 70% maximal oxygen uptake, following carbohydrate intake. Blood samples were collected pre-exercise and 0 min, 30 min, 1 h, 3 h and 24 h after the cessation of exercise. Serum FGF21 levels were measured by an enzyme-linked immunosorbent assay. Results: Higher serum FGF21 was observed in the elderly subjects group throughout the experiment (P < 0·05). There was no significant increase in serum FGF21 levels after the cessation of exercise, whereas serum FGF21 levels were significantly lower 24 h after the exercise compared with those pre-exercise, 0 min, 30 min and 1 h after the cessation of exercise in both groups (P < 0·01). The response did not differ between the two groups because of no significant group × time interaction. Conclusions: Acute endurance exercise lowers serum FGF21 levels 24 h following exercise. The results suggest that acute endurance exercise modulates postprandial FGF21 metabolism regardless of age.

Original languageEnglish
Pages (from-to)861-867
Number of pages7
JournalClinical Endocrinology
Volume85
Issue number6
DOIs
Publication statusPublished - 2016 Dec 1

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Exercise
Serum
fibroblast growth factor 21
Limit of Detection
Enzyme-Linked Immunosorbent Assay
Carbohydrates
Oxygen

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Acute endurance exercise lowers serum fibroblast growth factor 21 levels in Japanese men. / Taniguchi, Hirokazu; Tanisawa, Kumpei; Sun, Xiaomin; Higuchi, Mitsuru.

In: Clinical Endocrinology, Vol. 85, No. 6, 01.12.2016, p. 861-867.

Research output: Contribution to journalArticle

Taniguchi, Hirokazu ; Tanisawa, Kumpei ; Sun, Xiaomin ; Higuchi, Mitsuru. / Acute endurance exercise lowers serum fibroblast growth factor 21 levels in Japanese men. In: Clinical Endocrinology. 2016 ; Vol. 85, No. 6. pp. 861-867.
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abstract = "Objective: The independent effects of acute endurance exercise on FGF21 metabolism are poorly understood. Therefore, the purpose of this study was to determine whether acute endurance exercise modulates serum postprandial FGF21 levels in an age-dependent manner. Design: Exercise intervention trial. Patients: Twenty-eight subjects participated in the experiment, of whom 13 were excluded mainly because of a serum FGF21 level below the limit of detection. Thus, data from seven young (age: 18–22 years) and eight elderly male subjects (age: 62–69 years) were analysed. Measurements: Participants were asked to perform a cycling exercise for 30 min at 70{\%} maximal oxygen uptake, following carbohydrate intake. Blood samples were collected pre-exercise and 0 min, 30 min, 1 h, 3 h and 24 h after the cessation of exercise. Serum FGF21 levels were measured by an enzyme-linked immunosorbent assay. Results: Higher serum FGF21 was observed in the elderly subjects group throughout the experiment (P < 0·05). There was no significant increase in serum FGF21 levels after the cessation of exercise, whereas serum FGF21 levels were significantly lower 24 h after the exercise compared with those pre-exercise, 0 min, 30 min and 1 h after the cessation of exercise in both groups (P < 0·01). The response did not differ between the two groups because of no significant group × time interaction. Conclusions: Acute endurance exercise lowers serum FGF21 levels 24 h following exercise. The results suggest that acute endurance exercise modulates postprandial FGF21 metabolism regardless of age.",
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