Adaptation to exercise-induced oxidative stress

From muscle to brain

Zsolt Radak, A. W. Taylor, H. Ohno, S. Goto

Research output: Contribution to journalReview article

219 Citations (Scopus)

Abstract

Exercise increases the generation of reactive oxygen and nitrogen species (RONS) and by causing adaptation, could decrease the incidence of RONS-associated diseases. A single bout of exercise, depending upon intensity and duration, can cause an increase in antioxidant enzyme activity, decrease levels of thiols and antioxidant vitamins, and result in oxidative damage as a sign of incomplete adaptation. Increased levels of RONS and oxidative damage are initiators of a specific adaptive response, such as the stimulation of the activation of antioxidant enzymes, thiols, and enhanced oxidative damage repair. Regular exercise has the capability to develop compensation to oxidative stress, resulting in overcompensation against the increased level of RONS production and oxidative damage. Regular exercise causes adaptation of the antioxidant and repair systems, which could result in a decreased base level of oxidative damage and increased resistance to oxidative stress.

Original languageEnglish
Pages (from-to)90-107
Number of pages18
JournalExercise immunology review
Volume7
Publication statusPublished - 2001 Oct 10
Externally publishedYes

Fingerprint

Reactive Nitrogen Species
Reactive Oxygen Species
Oxidative Stress
Antioxidants
Muscles
Brain
Sulfhydryl Compounds
Enzyme Activation
Vitamins
Incidence
Enzymes

Keywords

  • Carbonic anhydrase
  • Carbonyls
  • DNA damage
  • Lipid peroxidation
  • Reactive oxygen and nitrogen species

ASJC Scopus subject areas

  • Immunology

Cite this

Adaptation to exercise-induced oxidative stress : From muscle to brain. / Radak, Zsolt; Taylor, A. W.; Ohno, H.; Goto, S.

In: Exercise immunology review, Vol. 7, 10.10.2001, p. 90-107.

Research output: Contribution to journalReview article

Radak, Zsolt ; Taylor, A. W. ; Ohno, H. ; Goto, S. / Adaptation to exercise-induced oxidative stress : From muscle to brain. In: Exercise immunology review. 2001 ; Vol. 7. pp. 90-107.
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