Abstract
Freestanding biodegradable nanosheets composed of poly(l-lactic acid) (PLLA) have been developed for various biomedical applications. These nanosheets exhibit unique properties such as high adhesiveness and exquisite flexibility; however, they burst easily due to their nanometer thickness. We herein describe a freestanding, multilayered nanosheet composed of PLLA fabricated using a simple combination procedure: (i) multilayering of PLLA and alginate, (ii) gelation of the alginate layers, (iii) fusion-cut sealing, and (iv) elution of the alginate layers. The multilayered nanosheets not only reinforced the bursting strength but also provided a high level of adhesive strength. In fact, they were found to show potential as a hemostatic dressing, and they tended to show reduced tissue adhesion that accompanies liver injury. Therefore, we propose this biomaterial as a candidate for an alternative to conventional therapy in hemorrhage.
Original language | English |
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Journal | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
DOIs | |
Publication status | Accepted/In press - 2016 |
Keywords
- Hemostatic dressings
- Liver injury
- Multilayer
- Nanosheet
- Poly(lactic acid)
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials