Adhesive and Robust Multilayered Poly(lactic acid) Nanosheets for Hemostatic Dressing in Liver Injury Model

Takuya Komachi, Hideaki Sumiyoshi, Yutaka Inagaki, Shinji Takeoka, Yu Nagase, Yosuke Okamura

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Freestanding biodegradable nanosheets composed of poly(l-lactic acid) (PLLA) have been developed for various biomedical applications. These nanosheets exhibit unique properties such as high adhesiveness and exquisite flexibility; however, they burst easily due to their nanometer thickness. We herein describe a freestanding, multilayered nanosheet composed of PLLA fabricated using a simple combination procedure: (i) multilayering of PLLA and alginate, (ii) gelation of the alginate layers, (iii) fusion-cut sealing, and (iv) elution of the alginate layers. The multilayered nanosheets not only reinforced the bursting strength but also provided a high level of adhesive strength. In fact, they were found to show potential as a hemostatic dressing, and they tended to show reduced tissue adhesion that accompanies liver injury. Therefore, we propose this biomaterial as a candidate for an alternative to conventional therapy in hemorrhage.

    Original languageEnglish
    JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
    DOIs
    Publication statusAccepted/In press - 2016

    Keywords

    • Hemostatic dressings
    • Liver injury
    • Multilayer
    • Nanosheet
    • Poly(lactic acid)

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Biomaterials

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