Adhesive and robust multilayered poly(lactic acid) nanosheets for hemostatic dressing in liver injury model

Takuya Komachi, Hideaki Sumiyoshi, Yutaka Inagaki, Shinji Takeoka, Yu Nagase, Yosuke Okamura

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Freestanding biodegradable nanosheets composed of poly(l-lactic acid) (PLLA) have been developed for various biomedical applications. These nanosheets exhibit unique properties such as high adhesiveness and exquisite flexibility; however, they burst easily due to their nanometer thickness. We herein describe a freestanding, multilayered nanosheet composed of PLLA fabricated using a simple combination procedure: (i) multilayering of PLLA and alginate, (ii) gelation of the alginate layers, (iii) fusion-cut sealing, and (iv) elution of the alginate layers. The multilayered nanosheets not only reinforced the bursting strength but also provided a high level of adhesive strength. In fact, they were found to show potential as a hemostatic dressing, and they tended to show reduced tissue adhesion that accompanies liver injury. Therefore, we propose this biomaterial as a candidate for an alternative to conventional therapy in hemorrhage.

Original languageEnglish
Pages (from-to)1747-1757
Number of pages11
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume105
Issue number7
DOIs
Publication statusPublished - 2017 Oct

Keywords

  • hemostatic dressings
  • liver injury
  • multilayer
  • nanosheet
  • poly(lactic acid)

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Fingerprint

Dive into the research topics of 'Adhesive and robust multilayered poly(lactic acid) nanosheets for hemostatic dressing in liver injury model'. Together they form a unique fingerprint.

Cite this