Adhesive, flexible, and robust polysaccharide nanosheets integrated for tissue-defect repair

Toshinori Fujie, Noriyuki Matsutani, Manabu Kinoshita, Yosuke Okamura, Akihiro Saito, Shinji Takeoka

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Recent developments in nanotechnology have led to a method for producing free-standing polymer nanosheets as a macromolecular organization. Compared with bulk films, the large aspect ratio of such nanosheets leads to unique physical properties, such as transparency, noncovalent adhesion, and high flexibility. Here, a biomedical application of polymer nanosheets consisting of biocompatible and biodegradable polysaccharides is reported. Micro-scratch and bulge tests indicate that the nanosheets with a thickness of tens of nanometers have sufficient physical adhesiveness and mechanical strength for clinical use. A nanosheet of 75 nm thickness, a critical load of 9.1 X 104 N m -1 and an elastic modulus of 9.6 GPa is used for the minimally invasive repair of a visceral pleural defect in beagle dogs without any pleural adhesion caused by wound repair. For the first time, clinical benefits of sheettype nano-biomaterials based on molecular organization are demonstrated, suggesting that novel therapeutic tools for overlapping tissue wounds will be possible without the need for conventional surgical interventions.

Original languageEnglish
Pages (from-to)2560-2568
Number of pages9
JournalAdvanced Functional Materials
Volume19
Issue number16
DOIs
Publication statusPublished - 2009

Fingerprint

Nanosheets
polysaccharides
Polysaccharides
adhesives
Adhesives
adhesion
Repair
Tissue
Defects
dogs
defects
polymers
nanotechnology
aspect ratio
modulus of elasticity
flexibility
physical properties
Polymers
Adhesion
Biocompatible Materials

ASJC Scopus subject areas

  • Biomaterials
  • Electrochemistry
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Adhesive, flexible, and robust polysaccharide nanosheets integrated for tissue-defect repair. / Fujie, Toshinori; Matsutani, Noriyuki; Kinoshita, Manabu; Okamura, Yosuke; Saito, Akihiro; Takeoka, Shinji.

In: Advanced Functional Materials, Vol. 19, No. 16, 2009, p. 2560-2568.

Research output: Contribution to journalArticle

Fujie, Toshinori ; Matsutani, Noriyuki ; Kinoshita, Manabu ; Okamura, Yosuke ; Saito, Akihiro ; Takeoka, Shinji. / Adhesive, flexible, and robust polysaccharide nanosheets integrated for tissue-defect repair. In: Advanced Functional Materials. 2009 ; Vol. 19, No. 16. pp. 2560-2568.
@article{dc771628a7bc4d1f8e3e15b67100fa1c,
title = "Adhesive, flexible, and robust polysaccharide nanosheets integrated for tissue-defect repair",
abstract = "Recent developments in nanotechnology have led to a method for producing free-standing polymer nanosheets as a macromolecular organization. Compared with bulk films, the large aspect ratio of such nanosheets leads to unique physical properties, such as transparency, noncovalent adhesion, and high flexibility. Here, a biomedical application of polymer nanosheets consisting of biocompatible and biodegradable polysaccharides is reported. Micro-scratch and bulge tests indicate that the nanosheets with a thickness of tens of nanometers have sufficient physical adhesiveness and mechanical strength for clinical use. A nanosheet of 75 nm thickness, a critical load of 9.1 X 104 N m -1 and an elastic modulus of 9.6 GPa is used for the minimally invasive repair of a visceral pleural defect in beagle dogs without any pleural adhesion caused by wound repair. For the first time, clinical benefits of sheettype nano-biomaterials based on molecular organization are demonstrated, suggesting that novel therapeutic tools for overlapping tissue wounds will be possible without the need for conventional surgical interventions.",
author = "Toshinori Fujie and Noriyuki Matsutani and Manabu Kinoshita and Yosuke Okamura and Akihiro Saito and Shinji Takeoka",
year = "2009",
doi = "10.1002/adfm.200900103",
language = "English",
volume = "19",
pages = "2560--2568",
journal = "Advanced Materials for Optics and Electronics",
issn = "1057-9257",
publisher = "Wiley-VCH Verlag",
number = "16",

}

TY - JOUR

T1 - Adhesive, flexible, and robust polysaccharide nanosheets integrated for tissue-defect repair

AU - Fujie, Toshinori

AU - Matsutani, Noriyuki

AU - Kinoshita, Manabu

AU - Okamura, Yosuke

AU - Saito, Akihiro

AU - Takeoka, Shinji

PY - 2009

Y1 - 2009

N2 - Recent developments in nanotechnology have led to a method for producing free-standing polymer nanosheets as a macromolecular organization. Compared with bulk films, the large aspect ratio of such nanosheets leads to unique physical properties, such as transparency, noncovalent adhesion, and high flexibility. Here, a biomedical application of polymer nanosheets consisting of biocompatible and biodegradable polysaccharides is reported. Micro-scratch and bulge tests indicate that the nanosheets with a thickness of tens of nanometers have sufficient physical adhesiveness and mechanical strength for clinical use. A nanosheet of 75 nm thickness, a critical load of 9.1 X 104 N m -1 and an elastic modulus of 9.6 GPa is used for the minimally invasive repair of a visceral pleural defect in beagle dogs without any pleural adhesion caused by wound repair. For the first time, clinical benefits of sheettype nano-biomaterials based on molecular organization are demonstrated, suggesting that novel therapeutic tools for overlapping tissue wounds will be possible without the need for conventional surgical interventions.

AB - Recent developments in nanotechnology have led to a method for producing free-standing polymer nanosheets as a macromolecular organization. Compared with bulk films, the large aspect ratio of such nanosheets leads to unique physical properties, such as transparency, noncovalent adhesion, and high flexibility. Here, a biomedical application of polymer nanosheets consisting of biocompatible and biodegradable polysaccharides is reported. Micro-scratch and bulge tests indicate that the nanosheets with a thickness of tens of nanometers have sufficient physical adhesiveness and mechanical strength for clinical use. A nanosheet of 75 nm thickness, a critical load of 9.1 X 104 N m -1 and an elastic modulus of 9.6 GPa is used for the minimally invasive repair of a visceral pleural defect in beagle dogs without any pleural adhesion caused by wound repair. For the first time, clinical benefits of sheettype nano-biomaterials based on molecular organization are demonstrated, suggesting that novel therapeutic tools for overlapping tissue wounds will be possible without the need for conventional surgical interventions.

UR - http://www.scopus.com/inward/record.url?scp=70349231472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349231472&partnerID=8YFLogxK

U2 - 10.1002/adfm.200900103

DO - 10.1002/adfm.200900103

M3 - Article

AN - SCOPUS:70349231472

VL - 19

SP - 2560

EP - 2568

JO - Advanced Materials for Optics and Electronics

JF - Advanced Materials for Optics and Electronics

SN - 1057-9257

IS - 16

ER -