Adhesive, flexible, and robust polysaccharide nanosheets integrated for tissue-defect repair

Toshinori Fujie, Noriyuki Matsutani, Manabu Kinoshita, Yosuke Okamura, Akihiro Saito, Shinji Takeoka

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Recent developments in nanotechnology have led to a method for producing free-standing polymer nanosheets as a macromolecular organization. Compared with bulk films, the large aspect ratio of such nanosheets leads to unique physical properties, such as transparency, noncovalent adhesion, and high flexibility. Here, a biomedical application of polymer nanosheets consisting of biocompatible and biodegradable polysaccharides is reported. Micro-scratch and bulge tests indicate that the nanosheets with a thickness of tens of nanometers have sufficient physical adhesiveness and mechanical strength for clinical use. A nanosheet of 75 nm thickness, a critical load of 9.1 X 104 N m -1 and an elastic modulus of 9.6 GPa is used for the minimally invasive repair of a visceral pleural defect in beagle dogs without any pleural adhesion caused by wound repair. For the first time, clinical benefits of sheettype nano-biomaterials based on molecular organization are demonstrated, suggesting that novel therapeutic tools for overlapping tissue wounds will be possible without the need for conventional surgical interventions.

Original languageEnglish
Pages (from-to)2560-2568
Number of pages9
JournalAdvanced Functional Materials
Volume19
Issue number16
DOIs
Publication statusPublished - 2009 Sep 24

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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