Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress

Tomohito Hamazaki, Shigeki Sawazaki, Tetsuro Nagasawa, Yoko Nagao, Yuko Kanagawa, Kazunaga Yazawa

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The purpose of the present research was to clarify the effect of docosahexaenoic acid (DHA) intake on behavior and plasma catecholamines (CA). In Study 1, 42 students took either DHA-rich oil capsules containing 1.5-1.8 g DHA/d or control oil capsules containing 97% soybean oil plus 3% of another fish oil for 3 mon in a double-blind fashion. They took a psychological test (PF study) at the start and end of the study. This study started at the end of summer vacation and ended just before the final exams. In the control group, external aggression (aggression against others) in PF Study was significantly increased at the end of the study as compared with that measured at the start (+8.9%), whereas it was not significantly changed in the DHA group (-1.0%). In a similar double-blind study (Study 2), we measured external aggression under nonstressful conditions. External aggression slightly decreased in the control group, whereas there were no significant changes in the DHA group. In Study 3 with 14 students, plasma CA were measured at the start and end of capsule administration period of 2 mon. Subjects were under continuous stress of the final exams that lasted throughout the whole study period. The ratio of plasma epinephrine to norepinephrine concentrations was significantly increased in the DHA group (78%), whereas it stayed at the same level in the control group. In Study 4, mice were fed either DHA-deficient diet or -sufficient diet for 4 wk, and their rearing frequency (an anxiety index) was measured. In the DHA- sufficient group, the rearing frequency was significantly less than in the other group. These effects of DHA intake may be applied to people in an attempt to ameliorate stress-related diseases.

Original languageEnglish
JournalLipids
Volume34
Issue number6 SUPPL.
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Docosahexaenoic Acids
catecholamines
docosahexaenoic acid
Psychological Stress
Catecholamines
Plasmas
Aggression
aggression
Capsules
Nutrition
Control Groups
Oils
students
rearing
vacations
Students
Diet
Psychological Tests
oils
Soybean Oil

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Biochemistry

Cite this

Hamazaki, T., Sawazaki, S., Nagasawa, T., Nagao, Y., Kanagawa, Y., & Yazawa, K. (1999). Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. Lipids, 34(6 SUPPL.).

Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. / Hamazaki, Tomohito; Sawazaki, Shigeki; Nagasawa, Tetsuro; Nagao, Yoko; Kanagawa, Yuko; Yazawa, Kazunaga.

In: Lipids, Vol. 34, No. 6 SUPPL., 1999.

Research output: Contribution to journalArticle

Hamazaki, T, Sawazaki, S, Nagasawa, T, Nagao, Y, Kanagawa, Y & Yazawa, K 1999, 'Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress', Lipids, vol. 34, no. 6 SUPPL..
Hamazaki T, Sawazaki S, Nagasawa T, Nagao Y, Kanagawa Y, Yazawa K. Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. Lipids. 1999;34(6 SUPPL.).
Hamazaki, Tomohito ; Sawazaki, Shigeki ; Nagasawa, Tetsuro ; Nagao, Yoko ; Kanagawa, Yuko ; Yazawa, Kazunaga. / Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. In: Lipids. 1999 ; Vol. 34, No. 6 SUPPL.
@article{0b0fa502e31d43eabdd0b5d87e0ad261,
title = "Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress",
abstract = "The purpose of the present research was to clarify the effect of docosahexaenoic acid (DHA) intake on behavior and plasma catecholamines (CA). In Study 1, 42 students took either DHA-rich oil capsules containing 1.5-1.8 g DHA/d or control oil capsules containing 97{\%} soybean oil plus 3{\%} of another fish oil for 3 mon in a double-blind fashion. They took a psychological test (PF study) at the start and end of the study. This study started at the end of summer vacation and ended just before the final exams. In the control group, external aggression (aggression against others) in PF Study was significantly increased at the end of the study as compared with that measured at the start (+8.9{\%}), whereas it was not significantly changed in the DHA group (-1.0{\%}). In a similar double-blind study (Study 2), we measured external aggression under nonstressful conditions. External aggression slightly decreased in the control group, whereas there were no significant changes in the DHA group. In Study 3 with 14 students, plasma CA were measured at the start and end of capsule administration period of 2 mon. Subjects were under continuous stress of the final exams that lasted throughout the whole study period. The ratio of plasma epinephrine to norepinephrine concentrations was significantly increased in the DHA group (78{\%}), whereas it stayed at the same level in the control group. In Study 4, mice were fed either DHA-deficient diet or -sufficient diet for 4 wk, and their rearing frequency (an anxiety index) was measured. In the DHA- sufficient group, the rearing frequency was significantly less than in the other group. These effects of DHA intake may be applied to people in an attempt to ameliorate stress-related diseases.",
author = "Tomohito Hamazaki and Shigeki Sawazaki and Tetsuro Nagasawa and Yoko Nagao and Yuko Kanagawa and Kazunaga Yazawa",
year = "1999",
language = "English",
volume = "34",
journal = "Lipids",
issn = "0024-4201",
publisher = "Springer Verlag",
number = "6 SUPPL.",

}

TY - JOUR

T1 - Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress

AU - Hamazaki, Tomohito

AU - Sawazaki, Shigeki

AU - Nagasawa, Tetsuro

AU - Nagao, Yoko

AU - Kanagawa, Yuko

AU - Yazawa, Kazunaga

PY - 1999

Y1 - 1999

N2 - The purpose of the present research was to clarify the effect of docosahexaenoic acid (DHA) intake on behavior and plasma catecholamines (CA). In Study 1, 42 students took either DHA-rich oil capsules containing 1.5-1.8 g DHA/d or control oil capsules containing 97% soybean oil plus 3% of another fish oil for 3 mon in a double-blind fashion. They took a psychological test (PF study) at the start and end of the study. This study started at the end of summer vacation and ended just before the final exams. In the control group, external aggression (aggression against others) in PF Study was significantly increased at the end of the study as compared with that measured at the start (+8.9%), whereas it was not significantly changed in the DHA group (-1.0%). In a similar double-blind study (Study 2), we measured external aggression under nonstressful conditions. External aggression slightly decreased in the control group, whereas there were no significant changes in the DHA group. In Study 3 with 14 students, plasma CA were measured at the start and end of capsule administration period of 2 mon. Subjects were under continuous stress of the final exams that lasted throughout the whole study period. The ratio of plasma epinephrine to norepinephrine concentrations was significantly increased in the DHA group (78%), whereas it stayed at the same level in the control group. In Study 4, mice were fed either DHA-deficient diet or -sufficient diet for 4 wk, and their rearing frequency (an anxiety index) was measured. In the DHA- sufficient group, the rearing frequency was significantly less than in the other group. These effects of DHA intake may be applied to people in an attempt to ameliorate stress-related diseases.

AB - The purpose of the present research was to clarify the effect of docosahexaenoic acid (DHA) intake on behavior and plasma catecholamines (CA). In Study 1, 42 students took either DHA-rich oil capsules containing 1.5-1.8 g DHA/d or control oil capsules containing 97% soybean oil plus 3% of another fish oil for 3 mon in a double-blind fashion. They took a psychological test (PF study) at the start and end of the study. This study started at the end of summer vacation and ended just before the final exams. In the control group, external aggression (aggression against others) in PF Study was significantly increased at the end of the study as compared with that measured at the start (+8.9%), whereas it was not significantly changed in the DHA group (-1.0%). In a similar double-blind study (Study 2), we measured external aggression under nonstressful conditions. External aggression slightly decreased in the control group, whereas there were no significant changes in the DHA group. In Study 3 with 14 students, plasma CA were measured at the start and end of capsule administration period of 2 mon. Subjects were under continuous stress of the final exams that lasted throughout the whole study period. The ratio of plasma epinephrine to norepinephrine concentrations was significantly increased in the DHA group (78%), whereas it stayed at the same level in the control group. In Study 4, mice were fed either DHA-deficient diet or -sufficient diet for 4 wk, and their rearing frequency (an anxiety index) was measured. In the DHA- sufficient group, the rearing frequency was significantly less than in the other group. These effects of DHA intake may be applied to people in an attempt to ameliorate stress-related diseases.

UR - http://www.scopus.com/inward/record.url?scp=0033000748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033000748&partnerID=8YFLogxK

M3 - Article

C2 - 10419086

AN - SCOPUS:0033000748

VL - 34

JO - Lipids

JF - Lipids

SN - 0024-4201

IS - 6 SUPPL.

ER -