Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8

Makoto Asai; Masayuki Ikeda; Masashi Akiyama; Itsuki Oshima; Shigenobu Shibata

doi:10.1016/S0006-8993(00)02661-5

Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8

Makoto Asai, Masayuki Ikeda, Masashi Akiyama, Itsuki Oshima, Shigenobu Shibata^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (τ) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MT1 and MT2 receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	220-224
Number of pages	5
Journal	Brain Research
Volume	876
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(00)02661-5
Publication status	Published - 2000 Sept 8

Keywords

Aging
Locomotor activity
Melatonin
Polymerase chain reaction

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)02661-5

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title = "Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8",

abstract = "We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (τ) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MT1 and MT2 receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice. (C) 2000 Elsevier Science B.V.",

keywords = "Aging, Locomotor activity, Melatonin, Polymerase chain reaction",

author = "Makoto Asai and Masayuki Ikeda and Masashi Akiyama and Itsuki Oshima and Shigenobu Shibata",

note = "Funding Information: We would like to thank Dr Charles N. Allen (Oregon Health Sciences University) for helpful comments on this manuscript. This study was supported by Grants-in-Aid to S.S. from the Ministry of Education, Science, Sports and Culture of Japan and from Waseda University (96A-302).",

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doi = "10.1016/S0006-8993(00)02661-5",

language = "English",

volume = "876",

pages = "220--224",

journal = "Brain Research",

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TY - JOUR

T1 - Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8

AU - Asai, Makoto

AU - Ikeda, Masayuki

AU - Akiyama, Masashi

AU - Oshima, Itsuki

AU - Shibata, Shigenobu

N1 - Funding Information: We would like to thank Dr Charles N. Allen (Oregon Health Sciences University) for helpful comments on this manuscript. This study was supported by Grants-in-Aid to S.S. from the Ministry of Education, Science, Sports and Culture of Japan and from Waseda University (96A-302).

PY - 2000/9/8

Y1 - 2000/9/8

N2 - We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (τ) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MT1 and MT2 receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice. (C) 2000 Elsevier Science B.V.

AB - We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (τ) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MT1 and MT2 receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice. (C) 2000 Elsevier Science B.V.

KW - Aging

KW - Locomotor activity

KW - Melatonin

KW - Polymerase chain reaction

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U2 - 10.1016/S0006-8993(00)02661-5

DO - 10.1016/S0006-8993(00)02661-5

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AN - SCOPUS:0034623188

SN - 0006-8993

VL - 876

SP - 220

EP - 224

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8

Abstract

Keywords

ASJC Scopus subject areas

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