Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8

Makoto Asai, Masayuki Ikeda, Masashi Akiyama, Itsuki Oshima, Shigenobu Shibata

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (τ) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MT1 and MT2 receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)220-224
Number of pages5
JournalBrain Research
Volume876
Issue number1-2
DOIs
Publication statusPublished - 2000 Sep 8

Keywords

  • Aging
  • Locomotor activity
  • Melatonin
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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