Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8

Makoto Asai, Masayuki Ikeda, Masashi Akiyama, Itsuki Oshima, Shigenobu Shibata

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (τ) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MT1 and MT2 receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice. (C) 2000 Elsevier Science B.V.

    Original languageEnglish
    Pages (from-to)220-224
    Number of pages5
    JournalBrain Research
    Volume876
    Issue number1-2
    DOIs
    Publication statusPublished - 2000 Sep 8

    Fingerprint

    Photoperiod
    Melatonin
    Drinking Water
    Melatonin MT1 Receptor
    Melatonin MT2 Receptor
    Running
    Drinking

    Keywords

    • Aging
    • Locomotor activity
    • Melatonin
    • Polymerase chain reaction

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8. / Asai, Makoto; Ikeda, Masayuki; Akiyama, Masashi; Oshima, Itsuki; Shibata, Shigenobu.

    In: Brain Research, Vol. 876, No. 1-2, 08.09.2000, p. 220-224.

    Research output: Contribution to journalArticle

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