Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome

Nagisa Sugaya, Shuhei Izawa, Kenta Kimura, Namiko Ogawa, Kosuke C. Yamada, Kentaro Shirotsuki, Ikuyo Mikami, Kanako Hirata, Yuichiro Nagano, Shinobu Nomura, Hironori Shimada

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Objective: In this study, we investigated levels and relative ratios of adrenal hormones (including cortisol, dehydroepiandrosterone [DHEA], and DHEA-sulfate [DHEA-S]) and their psychophysiological correlates under acute psychosocial stress in individuals with irritable bowel syndrome (IBS). Methods: Fifty-three college students participated in the study (male: 42, female: 11; mean age: 22.64. years), including 13 individuals with IBS (IBS group) and 40 individuals without IBS (control group). The participants were exposed to a standardized laboratory stressor, which included delivering a speech and performing a mental arithmetic task. We measured subjective stress levels and salivary cortisol, DHEA, and DHEA-S levels at relevant time points before, during, and after the tasks. Results: DHEA-S level and the DHEA-S/DHEA ratio in the IBS group were significantly lower than those in the control group, and the cortisol/DHEA-S ratio in the IBS group was higher than that in the control group throughout the experiment. In the IBS group, the appraisal of a threat was positively correlated with cortisol levels (r= 0.61), and the appraisal of controllability was negatively correlated with cortisol levels (r= -0.64) and with the cortisol/DHEA ratio (r= -0.71). The control group showed a significant positive correlation between the appraisal of threat and cortisol levels (r= 0.32). Conclusion: The present study indicates that individuals with IBS had lower DHEA-S levels, and that their stressful cognitive appraisals under acute psychosocial stress caused the effects of cortisol to dominate. This adrenal hormone response may be involved in exacerbating abdominal symptoms in individuals with IBS.

    Original languageEnglish
    Pages (from-to)39-44
    Number of pages6
    JournalInternational Journal of Psychophysiology
    Volume84
    Issue number1
    DOIs
    Publication statusPublished - 2012 Apr

    Fingerprint

    Dehydroepiandrosterone
    Irritable Bowel Syndrome
    Hormones
    Hydrocortisone
    Control Groups
    Dehydroepiandrosterone Sulfate
    Students

    Keywords

    • Cognitive appraisal
    • Cortisol
    • Dehydroepiandrosterone
    • Irritable bowel syndrome
    • Psychological stress

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Physiology (medical)
    • Neuropsychology and Physiological Psychology

    Cite this

    Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome. / Sugaya, Nagisa; Izawa, Shuhei; Kimura, Kenta; Ogawa, Namiko; Yamada, Kosuke C.; Shirotsuki, Kentaro; Mikami, Ikuyo; Hirata, Kanako; Nagano, Yuichiro; Nomura, Shinobu; Shimada, Hironori.

    In: International Journal of Psychophysiology, Vol. 84, No. 1, 04.2012, p. 39-44.

    Research output: Contribution to journalArticle

    Sugaya, Nagisa ; Izawa, Shuhei ; Kimura, Kenta ; Ogawa, Namiko ; Yamada, Kosuke C. ; Shirotsuki, Kentaro ; Mikami, Ikuyo ; Hirata, Kanako ; Nagano, Yuichiro ; Nomura, Shinobu ; Shimada, Hironori. / Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome. In: International Journal of Psychophysiology. 2012 ; Vol. 84, No. 1. pp. 39-44.
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    abstract = "Objective: In this study, we investigated levels and relative ratios of adrenal hormones (including cortisol, dehydroepiandrosterone [DHEA], and DHEA-sulfate [DHEA-S]) and their psychophysiological correlates under acute psychosocial stress in individuals with irritable bowel syndrome (IBS). Methods: Fifty-three college students participated in the study (male: 42, female: 11; mean age: 22.64. years), including 13 individuals with IBS (IBS group) and 40 individuals without IBS (control group). The participants were exposed to a standardized laboratory stressor, which included delivering a speech and performing a mental arithmetic task. We measured subjective stress levels and salivary cortisol, DHEA, and DHEA-S levels at relevant time points before, during, and after the tasks. Results: DHEA-S level and the DHEA-S/DHEA ratio in the IBS group were significantly lower than those in the control group, and the cortisol/DHEA-S ratio in the IBS group was higher than that in the control group throughout the experiment. In the IBS group, the appraisal of a threat was positively correlated with cortisol levels (r= 0.61), and the appraisal of controllability was negatively correlated with cortisol levels (r= -0.64) and with the cortisol/DHEA ratio (r= -0.71). The control group showed a significant positive correlation between the appraisal of threat and cortisol levels (r= 0.32). Conclusion: The present study indicates that individuals with IBS had lower DHEA-S levels, and that their stressful cognitive appraisals under acute psychosocial stress caused the effects of cortisol to dominate. This adrenal hormone response may be involved in exacerbating abdominal symptoms in individuals with IBS.",
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    author = "Nagisa Sugaya and Shuhei Izawa and Kenta Kimura and Namiko Ogawa and Yamada, {Kosuke C.} and Kentaro Shirotsuki and Ikuyo Mikami and Kanako Hirata and Yuichiro Nagano and Shinobu Nomura and Hironori Shimada",
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    AU - Sugaya, Nagisa

    AU - Izawa, Shuhei

    AU - Kimura, Kenta

    AU - Ogawa, Namiko

    AU - Yamada, Kosuke C.

    AU - Shirotsuki, Kentaro

    AU - Mikami, Ikuyo

    AU - Hirata, Kanako

    AU - Nagano, Yuichiro

    AU - Nomura, Shinobu

    AU - Shimada, Hironori

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