Adsorption mechanisms of emerging micro-pollutants with a clay mineral: Case of tramadol and doxepine pharmaceutical products

Thomas Thiebault, Regis Guegan, Mohammed Boussafir

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A sodium exchanged smectite clay mineral (Mt) was used as geo-sorbent for the adsorption of tramadol and doxepin: two pharmaceutical products (PPs) defined as emerging pollutants due to their presence at significant concentration in numerous water compartments. The adsorption isotherms for both the temperatures of 20 and 40°C and the derived data determined through the fitting procedure by using Langmuir, Freundlich and Dubinin-Radushkevich equation models explicitly pointed out that the sorption of both tramadol and doxepin is mainly driven by electrostatic interaction. The studied PPs are intercalated in a monolayer arrangement within the interlayer space through a cation exchange in stoichiometric proportion with the Na+ cations leading to adsorbed PPs amounts that match the cation exchange capacity (CEC) of Mt. Due to their hydrophobic character, additional doxepin molecules could be adsorbed by weak molecular interaction driving to an increase of the adsorbed amount beyond the CEC at low temperature (20°C). The confinement of PPs within the interlayer space of Mt confirms the use of clay minerals as potential material for the wastewater treatment as well as it drives to an amorphous or glassy state, which can find echo in biopharmaceutical applications for a controlled release of PPs.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Colloid and Interface Science
Volume453
DOIs
Publication statusPublished - 2015 Sep 1
Externally publishedYes

Fingerprint

Tramadol
Clay minerals
Drug products
Doxepin
Cations
Adsorption
Positive ions
Ion exchange
Pharmaceutical Preparations
Molecular interactions
Sorbents
Coulomb interactions
Adsorption isotherms
Wastewater treatment
Sorption
Monolayers
Sodium
Temperature
Molecules
Water

Keywords

  • Adsorption
  • Amorphous systems
  • Clay mineral
  • Pharmaceutical products

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

Cite this

Adsorption mechanisms of emerging micro-pollutants with a clay mineral : Case of tramadol and doxepine pharmaceutical products. / Thiebault, Thomas; Guegan, Regis; Boussafir, Mohammed.

In: Journal of Colloid and Interface Science, Vol. 453, 01.09.2015, p. 1-8.

Research output: Contribution to journalArticle

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