Adsorption of bovine serum albumin to a polymer brush prepared by atom-transfer radical polymerization in a porous inorganic membrane

Hidetaka Kawakita, Hiroyasu Masunaga, Kanako Nomura, Kazuya Uezu, Isamu Akiba, Satoshi Tsuneda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Protein adsorption was performed by a polymer brush prepared by atom-transfer radical polymerization (ATRP) to a porous inorganic membrane. The porous inorganic membrane, Shirasu Porous Glass made from silica, was modified with a halogen-containing compound to bind the active species for the polymerization. Glycidyl methacrylate was polymerized from the halogen compound by ATRP for a prescribed time, and subsequently chemically modified. The progression of the chemical modification allowed the membrane to lower the phosphate-buffer flux of the porous membrane due to the attachment of the polymer brush. Bovine serum albumin (BSA), as a model protein, was adsorbed at 12 mg per gram of the membrane in permeating BSA solution through the polymer-brush-attached porous membrane.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalJournal of Porous Materials
Volume14
Issue number4
DOIs
Publication statusPublished - 2007 Nov 1

Keywords

  • Adsorption
  • Atom-transfer radical polymerization
  • Bovine serum albumin
  • Polymer brush
  • Shirasu porous glass

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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