Advance in animal experiments with the undulation pump total artificial heart

50 and 54 day survival periods with 1/R control

Yusuke Abe, Tsuneo Chinzei, Takashi Isoyama, Shinichi Kobayashi, Toshiya Ono, Itsuro Saito, Kiyotaka Iwasaki, Mitsuhiko Ishimaru, Atsushi Baba, Akimasa Kouno, Toshinaga Ozeki, Takahiro Tohyama, Kou Imachi

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    The undulation pump total artificial heart (UPTAH) is a unique, implantable, total artificial heart (TAH) that uses undulation pumps. To achieve long-term survival in animals with physiologic hemodynamic conditions, a control method based on conductance and arterial pressure was applied to UPTAH. With this control method, called 1/R control, survival periods of 50 days (No. 0016, 49.6 kg) and 54 days (No. 0030, 42.5 kg) were obtained in adult female goats. In No. 0016, 1/R control was applied to the left pump, whereas in No. 0030, it was applied to the right pump. Another pump was used for left-right balance control. The control stability was better in No. 0030 than in No. 0016. The sucking effect of the left atrium was remarkable in No. 0016, possibly because of a time delay when left-right balance control was performed with the right pump. In No. 0016, the cause of death was probably a thrombus flown from a panus in the left atrium. It is possible that the left atrial suction effect influenced the thrombus and panus formation in the left atrium. In No. 0030, the cause of death was a small rupture of the membrane in the right pump. The rupture may have been caused by excessive negative pressure inside the pump. This pressure resulted from suction of the right atrium because of an unexpected control excursion, which was probably caused by a software bug. It will be necessary to redesign the undulation pump and improve the software to achieve longer survival periods for animals with physiologic hemodynamic conditions.

    Original languageEnglish
    Pages (from-to)325-332
    Number of pages8
    JournalASAIO Journal
    Volume49
    Issue number3
    DOIs
    Publication statusPublished - 2003 May

    Fingerprint

    Artificial heart
    Artificial Heart
    Heart Atria
    Animals
    Pumps
    Suction
    Rupture
    Cause of Death
    Thrombosis
    Software
    Hemodynamics
    Experiments
    Pressure
    Goats
    Arterial Pressure
    Membranes
    Time delay

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering

    Cite this

    Advance in animal experiments with the undulation pump total artificial heart : 50 and 54 day survival periods with 1/R control. / Abe, Yusuke; Chinzei, Tsuneo; Isoyama, Takashi; Kobayashi, Shinichi; Ono, Toshiya; Saito, Itsuro; Iwasaki, Kiyotaka; Ishimaru, Mitsuhiko; Baba, Atsushi; Kouno, Akimasa; Ozeki, Toshinaga; Tohyama, Takahiro; Imachi, Kou.

    In: ASAIO Journal, Vol. 49, No. 3, 05.2003, p. 325-332.

    Research output: Contribution to journalArticle

    Abe, Y, Chinzei, T, Isoyama, T, Kobayashi, S, Ono, T, Saito, I, Iwasaki, K, Ishimaru, M, Baba, A, Kouno, A, Ozeki, T, Tohyama, T & Imachi, K 2003, 'Advance in animal experiments with the undulation pump total artificial heart: 50 and 54 day survival periods with 1/R control', ASAIO Journal, vol. 49, no. 3, pp. 325-332. https://doi.org/10.1097/01.MAT.0000065371.07996.6F
    Abe, Yusuke ; Chinzei, Tsuneo ; Isoyama, Takashi ; Kobayashi, Shinichi ; Ono, Toshiya ; Saito, Itsuro ; Iwasaki, Kiyotaka ; Ishimaru, Mitsuhiko ; Baba, Atsushi ; Kouno, Akimasa ; Ozeki, Toshinaga ; Tohyama, Takahiro ; Imachi, Kou. / Advance in animal experiments with the undulation pump total artificial heart : 50 and 54 day survival periods with 1/R control. In: ASAIO Journal. 2003 ; Vol. 49, No. 3. pp. 325-332.
    @article{01eebda7ba3a40d38aa791abff5570ff,
    title = "Advance in animal experiments with the undulation pump total artificial heart: 50 and 54 day survival periods with 1/R control",
    abstract = "The undulation pump total artificial heart (UPTAH) is a unique, implantable, total artificial heart (TAH) that uses undulation pumps. To achieve long-term survival in animals with physiologic hemodynamic conditions, a control method based on conductance and arterial pressure was applied to UPTAH. With this control method, called 1/R control, survival periods of 50 days (No. 0016, 49.6 kg) and 54 days (No. 0030, 42.5 kg) were obtained in adult female goats. In No. 0016, 1/R control was applied to the left pump, whereas in No. 0030, it was applied to the right pump. Another pump was used for left-right balance control. The control stability was better in No. 0030 than in No. 0016. The sucking effect of the left atrium was remarkable in No. 0016, possibly because of a time delay when left-right balance control was performed with the right pump. In No. 0016, the cause of death was probably a thrombus flown from a panus in the left atrium. It is possible that the left atrial suction effect influenced the thrombus and panus formation in the left atrium. In No. 0030, the cause of death was a small rupture of the membrane in the right pump. The rupture may have been caused by excessive negative pressure inside the pump. This pressure resulted from suction of the right atrium because of an unexpected control excursion, which was probably caused by a software bug. It will be necessary to redesign the undulation pump and improve the software to achieve longer survival periods for animals with physiologic hemodynamic conditions.",
    author = "Yusuke Abe and Tsuneo Chinzei and Takashi Isoyama and Shinichi Kobayashi and Toshiya Ono and Itsuro Saito and Kiyotaka Iwasaki and Mitsuhiko Ishimaru and Atsushi Baba and Akimasa Kouno and Toshinaga Ozeki and Takahiro Tohyama and Kou Imachi",
    year = "2003",
    month = "5",
    doi = "10.1097/01.MAT.0000065371.07996.6F",
    language = "English",
    volume = "49",
    pages = "325--332",
    journal = "ASAIO Journal",
    issn = "1058-2916",
    publisher = "Lippincott Williams and Wilkins",
    number = "3",

    }

    TY - JOUR

    T1 - Advance in animal experiments with the undulation pump total artificial heart

    T2 - 50 and 54 day survival periods with 1/R control

    AU - Abe, Yusuke

    AU - Chinzei, Tsuneo

    AU - Isoyama, Takashi

    AU - Kobayashi, Shinichi

    AU - Ono, Toshiya

    AU - Saito, Itsuro

    AU - Iwasaki, Kiyotaka

    AU - Ishimaru, Mitsuhiko

    AU - Baba, Atsushi

    AU - Kouno, Akimasa

    AU - Ozeki, Toshinaga

    AU - Tohyama, Takahiro

    AU - Imachi, Kou

    PY - 2003/5

    Y1 - 2003/5

    N2 - The undulation pump total artificial heart (UPTAH) is a unique, implantable, total artificial heart (TAH) that uses undulation pumps. To achieve long-term survival in animals with physiologic hemodynamic conditions, a control method based on conductance and arterial pressure was applied to UPTAH. With this control method, called 1/R control, survival periods of 50 days (No. 0016, 49.6 kg) and 54 days (No. 0030, 42.5 kg) were obtained in adult female goats. In No. 0016, 1/R control was applied to the left pump, whereas in No. 0030, it was applied to the right pump. Another pump was used for left-right balance control. The control stability was better in No. 0030 than in No. 0016. The sucking effect of the left atrium was remarkable in No. 0016, possibly because of a time delay when left-right balance control was performed with the right pump. In No. 0016, the cause of death was probably a thrombus flown from a panus in the left atrium. It is possible that the left atrial suction effect influenced the thrombus and panus formation in the left atrium. In No. 0030, the cause of death was a small rupture of the membrane in the right pump. The rupture may have been caused by excessive negative pressure inside the pump. This pressure resulted from suction of the right atrium because of an unexpected control excursion, which was probably caused by a software bug. It will be necessary to redesign the undulation pump and improve the software to achieve longer survival periods for animals with physiologic hemodynamic conditions.

    AB - The undulation pump total artificial heart (UPTAH) is a unique, implantable, total artificial heart (TAH) that uses undulation pumps. To achieve long-term survival in animals with physiologic hemodynamic conditions, a control method based on conductance and arterial pressure was applied to UPTAH. With this control method, called 1/R control, survival periods of 50 days (No. 0016, 49.6 kg) and 54 days (No. 0030, 42.5 kg) were obtained in adult female goats. In No. 0016, 1/R control was applied to the left pump, whereas in No. 0030, it was applied to the right pump. Another pump was used for left-right balance control. The control stability was better in No. 0030 than in No. 0016. The sucking effect of the left atrium was remarkable in No. 0016, possibly because of a time delay when left-right balance control was performed with the right pump. In No. 0016, the cause of death was probably a thrombus flown from a panus in the left atrium. It is possible that the left atrial suction effect influenced the thrombus and panus formation in the left atrium. In No. 0030, the cause of death was a small rupture of the membrane in the right pump. The rupture may have been caused by excessive negative pressure inside the pump. This pressure resulted from suction of the right atrium because of an unexpected control excursion, which was probably caused by a software bug. It will be necessary to redesign the undulation pump and improve the software to achieve longer survival periods for animals with physiologic hemodynamic conditions.

    UR - http://www.scopus.com/inward/record.url?scp=0037542599&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0037542599&partnerID=8YFLogxK

    U2 - 10.1097/01.MAT.0000065371.07996.6F

    DO - 10.1097/01.MAT.0000065371.07996.6F

    M3 - Article

    VL - 49

    SP - 325

    EP - 332

    JO - ASAIO Journal

    JF - ASAIO Journal

    SN - 1058-2916

    IS - 3

    ER -