TY - JOUR
T1 - Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women
AU - Sanada, K.
AU - Iemitsu, M.
AU - Murakami, H.
AU - Gando, Y.
AU - Kawano, H.
AU - Kawakami, R.
AU - Tabata, I.
AU - Miyachi, M.
N1 - Funding Information:
This study was supported in part by a grant-in-aid (no. 21300258) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (KS) and a grant-in-aid for scientific research from the Ministry of Health, Labor, and Welfare of Japan (MM). The author’s responsibilities were as follows—DR Mitsuru Higuchi and DR Katsuhiko Suzuki: consulted on the study design, recruited subjects; DR Kenta Yamamoto, DR Hiroshi Kawano, DR Michiya Tanomoto, MS Yumi Ohmori and MR Satoshi Hanawa: acquisition of subjects and collection of data.
PY - 2012/10
Y1 - 2012/10
N2 - BACKGROUND/OBJECTIVES: Little information is available regarding the interactions of sarcopenia and metabolic syndrome (MetS) in the risks of these age-associated diseases in women. The present cross-sectional study was performed to investigate whether the coexistence of sarcopenia and MetS further increases the risks of lifestyle-related diseases in Japanese women.SUBJECTS/METHODS: Healthy Japanese women (n533) aged 30-84 participated in this study. MetS was defined as higher body mass index, fasting plasma glucose, systolic or diastolic blood pressure and blood lipid abnormalities. Appendicular muscle mass and bone mineral density (BMD) were measured using dual-energy X-ray absorptiometry. The criterion of low muscle mass and strength defined median skeletal muscle index (appendicular muscle mass/height 2, kg/m 2) and handgrip strength.RESULTS: Two-way ANCOVA with adjustment for age, body fat percentage and whole-body lean tissue mass indicated that sarcopenia and MetS interacted to produce a significant effect on HbA1c, systolic blood pressure, triglycerides and brachial-ankle pulse wave velocity in Japanese women. The systolic blood pressure, triglycerides and brachial-ankle pulse wave velocity were significantly higher in women with coexisting sarcopenia and MetS than in healthy controls or in those with sarcopenia or MetS alone. The HbA1c in the coexisting sarcopenia and MetS group was higher than in healthy controls and sarcopenia subjects.CONCLUSIONS: The coexistence of sarcopenia and MetS further increases the risks of cardiovascular diseases, such as type 2 diabetes mellitus, hypertension, arterial stiffness and hyperlipidemia even adjustment of age and body composition in adult Japanese women.
AB - BACKGROUND/OBJECTIVES: Little information is available regarding the interactions of sarcopenia and metabolic syndrome (MetS) in the risks of these age-associated diseases in women. The present cross-sectional study was performed to investigate whether the coexistence of sarcopenia and MetS further increases the risks of lifestyle-related diseases in Japanese women.SUBJECTS/METHODS: Healthy Japanese women (n533) aged 30-84 participated in this study. MetS was defined as higher body mass index, fasting plasma glucose, systolic or diastolic blood pressure and blood lipid abnormalities. Appendicular muscle mass and bone mineral density (BMD) were measured using dual-energy X-ray absorptiometry. The criterion of low muscle mass and strength defined median skeletal muscle index (appendicular muscle mass/height 2, kg/m 2) and handgrip strength.RESULTS: Two-way ANCOVA with adjustment for age, body fat percentage and whole-body lean tissue mass indicated that sarcopenia and MetS interacted to produce a significant effect on HbA1c, systolic blood pressure, triglycerides and brachial-ankle pulse wave velocity in Japanese women. The systolic blood pressure, triglycerides and brachial-ankle pulse wave velocity were significantly higher in women with coexisting sarcopenia and MetS than in healthy controls or in those with sarcopenia or MetS alone. The HbA1c in the coexisting sarcopenia and MetS group was higher than in healthy controls and sarcopenia subjects.CONCLUSIONS: The coexistence of sarcopenia and MetS further increases the risks of cardiovascular diseases, such as type 2 diabetes mellitus, hypertension, arterial stiffness and hyperlipidemia even adjustment of age and body composition in adult Japanese women.
KW - CVD risk factors
KW - body composition
KW - bone mineral density
KW - cardiorespiratory fitness
KW - metabolic syndrome
KW - sarcopenia
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U2 - 10.1038/ejcn.2012.43
DO - 10.1038/ejcn.2012.43
M3 - Article
C2 - 22569087
AN - SCOPUS:84867103021
VL - 66
SP - 1093
EP - 1098
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 10
ER -