Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women

K. Sanada, M. Iemitsu, H. Murakami, Y. Gando, H. Kawano, Ryoko Kawakami, I. Tabata, M. Miyachi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

BACKGROUND/OBJECTIVES: Little information is available regarding the interactions of sarcopenia and metabolic syndrome (MetS) in the risks of these age-associated diseases in women. The present cross-sectional study was performed to investigate whether the coexistence of sarcopenia and MetS further increases the risks of lifestyle-related diseases in Japanese women.SUBJECTS/METHODS: Healthy Japanese women (n533) aged 30-84 participated in this study. MetS was defined as higher body mass index, fasting plasma glucose, systolic or diastolic blood pressure and blood lipid abnormalities. Appendicular muscle mass and bone mineral density (BMD) were measured using dual-energy X-ray absorptiometry. The criterion of low muscle mass and strength defined median skeletal muscle index (appendicular muscle mass/height 2, kg/m 2) and handgrip strength.RESULTS: Two-way ANCOVA with adjustment for age, body fat percentage and whole-body lean tissue mass indicated that sarcopenia and MetS interacted to produce a significant effect on HbA1c, systolic blood pressure, triglycerides and brachial-ankle pulse wave velocity in Japanese women. The systolic blood pressure, triglycerides and brachial-ankle pulse wave velocity were significantly higher in women with coexisting sarcopenia and MetS than in healthy controls or in those with sarcopenia or MetS alone. The HbA1c in the coexisting sarcopenia and MetS group was higher than in healthy controls and sarcopenia subjects.CONCLUSIONS: The coexistence of sarcopenia and MetS further increases the risks of cardiovascular diseases, such as type 2 diabetes mellitus, hypertension, arterial stiffness and hyperlipidemia even adjustment of age and body composition in adult Japanese women.

Original languageEnglish
Pages (from-to)1093-1098
Number of pages6
JournalEuropean Journal of Clinical Nutrition
Volume66
Issue number10
DOIs
Publication statusPublished - 2012 Oct
Externally publishedYes

Fingerprint

Sarcopenia
Blood Pressure
Pulse Wave Analysis
Ankle
Triglycerides
Arm
Social Adjustment
Muscles
Vascular Stiffness
Photon Absorptiometry
Muscle Strength
Body Composition
Hyperlipidemias
Bone Density
Type 2 Diabetes Mellitus
Adipose Tissue
Life Style
Fasting
Skeletal Muscle
Body Mass Index

Keywords

  • body composition
  • bone mineral density
  • cardiorespiratory fitness
  • CVD risk factors
  • metabolic syndrome
  • sarcopenia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women. / Sanada, K.; Iemitsu, M.; Murakami, H.; Gando, Y.; Kawano, H.; Kawakami, Ryoko; Tabata, I.; Miyachi, M.

In: European Journal of Clinical Nutrition, Vol. 66, No. 10, 10.2012, p. 1093-1098.

Research output: Contribution to journalArticle

Sanada, K, Iemitsu, M, Murakami, H, Gando, Y, Kawano, H, Kawakami, R, Tabata, I & Miyachi, M 2012, 'Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women', European Journal of Clinical Nutrition, vol. 66, no. 10, pp. 1093-1098. https://doi.org/10.1038/ejcn.2012.43
Sanada, K. ; Iemitsu, M. ; Murakami, H. ; Gando, Y. ; Kawano, H. ; Kawakami, Ryoko ; Tabata, I. ; Miyachi, M. / Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women. In: European Journal of Clinical Nutrition. 2012 ; Vol. 66, No. 10. pp. 1093-1098.
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