Aerobic amide bond formation with N-hydroxysuccinimide

Haoyi Yao, Kana Yamamoto

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Breathe easy: Molecular oxygen is one of the most abundant, atom-efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc) 2 and N-hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity.

Original languageEnglish
Pages (from-to)1542-1545
Number of pages4
JournalChemistry - An Asian Journal
Volume7
Issue number7
DOIs
Publication statusPublished - 2012 Jun 1
Externally publishedYes

    Fingerprint

Keywords

  • amides
  • oxidation
  • oxygen
  • peptide coupling
  • synthetic methods

ASJC Scopus subject areas

  • Chemistry(all)
  • Medicine(all)

Cite this