Aerobic exercise training reduces epicardial fat in obese men

Maeng Kyu Kim, Tsugio Tomita, Mi Ji Kim, Hiroyuki Sasai, Seiji Maeda, Kiyoji Tanaka*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

145 Citations (Scopus)


The purpose of this study was to determine the effects of exercise training on ventricular epicardial fat thickness in obese men and to investigate the relationship of the change in epicardial fat thickness to changes in abdominal fat tissue following exercise training. Twenty-four obese middle-aged men [age, 49.4 ± 9.6 yr; weight, 87.7 ± 11.2 kg; body mass index (BMI), 30.7 ± 3.3 kg/m2; peak oxygen consumption, 28.4 ± 7.2 ml kg-1 min-1; means ± SD] participated in this study. Each participant completed a 12-wk supervised exercise training program (60-70% of the maximal heart rate; 60 min/day, 3 days/wk) and underwent a transthoracic echocardiography. The epicardial fat thickness on the free wall of the right ventricle was measured from both parasternal long- and short-axis views. The visceral adipose tissue (VAT) and subcutaneous adipose tissues were measured by computed tomography. Following exercise training, the epicardial fat thickness was significantly decreased (P < 0.001). The percentage change of epicardial fat thickness was twice as high compared with those of waist, BMI, and body weight of original values (P <0.05). There was a significant relationship (r = 0.525, P = 0.008) between changes in the epicardial fat thickness and VAT with exercise training. Stepwise multiple regression analysis revealed that the change in VAT, change in systolic blood pressure, and change in quantitative insulin sensitivity check index were independently related to the change epicardial fat thickness (P < 0.05). The ventricular epicardial fat thickness is reduced significantly after aerobic exercise training and is associated with a decrease in VAT. These results suggest that aerobic exercise training may be an effective nonpharmacological strategy for decreasing the ventricular epicardial fat thickness and visceral fat area in obese middle-aged men.

Original languageEnglish
Pages (from-to)5-11
Number of pages7
JournalJournal of Applied Physiology
Issue number1
Publication statusPublished - 2009 Jan
Externally publishedYes


  • Abdominal adiposity
  • Insulin resistance
  • Systolic blood pressure

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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