Aerobic training enhances muscle deoxygenation in early post-myocardial infarction

Shun Takagi, Norio Murase, Ryotaro Kime, Masatsugu Niwayama, Takuya Osada, Toshihito Katsumura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: Exercise-induced skeletal muscle deoxygenation is startling by its absence in early post-myocardial infarction (MI) patients. Exercise training early post-MI is associated with reduced cardiovascular risk and increased aerobic capacity. We therefore investigated whether aerobic training could enhance the muscle deoxygenation in early post-MI patients. Methods: 21 ± 8 days after the first MI patients (n = 16) were divided into 12-week aerobic training (TR, n = 10) or non-training (CON, n = 6) groups. Before and after intervention, patients performed ramp bicycle exercise until exhaustion. Muscle deoxygenation was measured at vastus lateralis by near-infrared spectroscopy during exercise. Results: Aerobic training significantly increased peak oxygen uptake (VO2) (18.1 ± 3.0 vs. 22.9 ± 2.8 mL/kg/min), decreased the change in muscle oxygen saturation from rest to submaximal and peak exercise (∆SmO2; 2.4 ± 5.7 vs. −7.0 ± 3.4 %), and increased the relative change in deoxygenated hemoglobin/myoglobin concentration from rest to submaximal (−1.5 ± 2.3 vs. 3.0 ± 3.6 μmol/L) and peak exercise (1.1 ± 4.5 vs. 8.2 ± 3.5 μmol/L). Change in total hemoglobin/myoglobin concentration in muscle was not significantly affected by training. In CON, no significant alterations were found after 12 weeks in either muscle deoxygenation or peak VO2 (18.6 ± 3.8 vs. 18.9 ± 4.6 mL/kg/min). An increase in peak VO2 was significantly negatively correlated with change in ∆SmO2 (r = −0.65) and positively associated with change in ∆deoxy-Hb/Mb at peak exercise (r = 0.64) in TR. Conclusions: In early post-MI patients, aerobic training enhanced skeletal muscle deoxygenation, and the enhancement was related to increased aerobic capacity.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalEuropean Journal of Applied Physiology
DOIs
Publication statusAccepted/In press - 2016 Jan 12

Fingerprint

Myocardial Infarction
Exercise
Muscles
Myoglobin
Hemoglobins
Skeletal Muscle
Oxygen
Architectural Accessibility
Near-Infrared Spectroscopy
Quadriceps Muscle

Keywords

  • Cycling training
  • Ischemic heart disease
  • Microcirculation
  • Near-infrared spectroscopy
  • Oxygen transport

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Orthopedics and Sports Medicine
  • Physiology (medical)

Cite this

Aerobic training enhances muscle deoxygenation in early post-myocardial infarction. / Takagi, Shun; Murase, Norio; Kime, Ryotaro; Niwayama, Masatsugu; Osada, Takuya; Katsumura, Toshihito.

In: European Journal of Applied Physiology, 12.01.2016, p. 1-13.

Research output: Contribution to journalArticle

Takagi, Shun ; Murase, Norio ; Kime, Ryotaro ; Niwayama, Masatsugu ; Osada, Takuya ; Katsumura, Toshihito. / Aerobic training enhances muscle deoxygenation in early post-myocardial infarction. In: European Journal of Applied Physiology. 2016 ; pp. 1-13.
@article{289f953e8b734ce3a2fbc036fa5a4fef,
title = "Aerobic training enhances muscle deoxygenation in early post-myocardial infarction",
abstract = "Purpose: Exercise-induced skeletal muscle deoxygenation is startling by its absence in early post-myocardial infarction (MI) patients. Exercise training early post-MI is associated with reduced cardiovascular risk and increased aerobic capacity. We therefore investigated whether aerobic training could enhance the muscle deoxygenation in early post-MI patients. Methods: 21 ± 8 days after the first MI patients (n = 16) were divided into 12-week aerobic training (TR, n = 10) or non-training (CON, n = 6) groups. Before and after intervention, patients performed ramp bicycle exercise until exhaustion. Muscle deoxygenation was measured at vastus lateralis by near-infrared spectroscopy during exercise. Results: Aerobic training significantly increased peak oxygen uptake (VO2) (18.1 ± 3.0 vs. 22.9 ± 2.8 mL/kg/min), decreased the change in muscle oxygen saturation from rest to submaximal and peak exercise (∆SmO2; 2.4 ± 5.7 vs. −7.0 ± 3.4 {\%}), and increased the relative change in deoxygenated hemoglobin/myoglobin concentration from rest to submaximal (−1.5 ± 2.3 vs. 3.0 ± 3.6 μmol/L) and peak exercise (1.1 ± 4.5 vs. 8.2 ± 3.5 μmol/L). Change in total hemoglobin/myoglobin concentration in muscle was not significantly affected by training. In CON, no significant alterations were found after 12 weeks in either muscle deoxygenation or peak VO2 (18.6 ± 3.8 vs. 18.9 ± 4.6 mL/kg/min). An increase in peak VO2 was significantly negatively correlated with change in ∆SmO2 (r = −0.65) and positively associated with change in ∆deoxy-Hb/Mb at peak exercise (r = 0.64) in TR. Conclusions: In early post-MI patients, aerobic training enhanced skeletal muscle deoxygenation, and the enhancement was related to increased aerobic capacity.",
keywords = "Cycling training, Ischemic heart disease, Microcirculation, Near-infrared spectroscopy, Oxygen transport",
author = "Shun Takagi and Norio Murase and Ryotaro Kime and Masatsugu Niwayama and Takuya Osada and Toshihito Katsumura",
year = "2016",
month = "1",
day = "12",
doi = "10.1007/s00421-016-3326-x",
language = "English",
pages = "1--13",
journal = "European Journal of Applied Physiology",
issn = "1439-6319",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Aerobic training enhances muscle deoxygenation in early post-myocardial infarction

AU - Takagi, Shun

AU - Murase, Norio

AU - Kime, Ryotaro

AU - Niwayama, Masatsugu

AU - Osada, Takuya

AU - Katsumura, Toshihito

PY - 2016/1/12

Y1 - 2016/1/12

N2 - Purpose: Exercise-induced skeletal muscle deoxygenation is startling by its absence in early post-myocardial infarction (MI) patients. Exercise training early post-MI is associated with reduced cardiovascular risk and increased aerobic capacity. We therefore investigated whether aerobic training could enhance the muscle deoxygenation in early post-MI patients. Methods: 21 ± 8 days after the first MI patients (n = 16) were divided into 12-week aerobic training (TR, n = 10) or non-training (CON, n = 6) groups. Before and after intervention, patients performed ramp bicycle exercise until exhaustion. Muscle deoxygenation was measured at vastus lateralis by near-infrared spectroscopy during exercise. Results: Aerobic training significantly increased peak oxygen uptake (VO2) (18.1 ± 3.0 vs. 22.9 ± 2.8 mL/kg/min), decreased the change in muscle oxygen saturation from rest to submaximal and peak exercise (∆SmO2; 2.4 ± 5.7 vs. −7.0 ± 3.4 %), and increased the relative change in deoxygenated hemoglobin/myoglobin concentration from rest to submaximal (−1.5 ± 2.3 vs. 3.0 ± 3.6 μmol/L) and peak exercise (1.1 ± 4.5 vs. 8.2 ± 3.5 μmol/L). Change in total hemoglobin/myoglobin concentration in muscle was not significantly affected by training. In CON, no significant alterations were found after 12 weeks in either muscle deoxygenation or peak VO2 (18.6 ± 3.8 vs. 18.9 ± 4.6 mL/kg/min). An increase in peak VO2 was significantly negatively correlated with change in ∆SmO2 (r = −0.65) and positively associated with change in ∆deoxy-Hb/Mb at peak exercise (r = 0.64) in TR. Conclusions: In early post-MI patients, aerobic training enhanced skeletal muscle deoxygenation, and the enhancement was related to increased aerobic capacity.

AB - Purpose: Exercise-induced skeletal muscle deoxygenation is startling by its absence in early post-myocardial infarction (MI) patients. Exercise training early post-MI is associated with reduced cardiovascular risk and increased aerobic capacity. We therefore investigated whether aerobic training could enhance the muscle deoxygenation in early post-MI patients. Methods: 21 ± 8 days after the first MI patients (n = 16) were divided into 12-week aerobic training (TR, n = 10) or non-training (CON, n = 6) groups. Before and after intervention, patients performed ramp bicycle exercise until exhaustion. Muscle deoxygenation was measured at vastus lateralis by near-infrared spectroscopy during exercise. Results: Aerobic training significantly increased peak oxygen uptake (VO2) (18.1 ± 3.0 vs. 22.9 ± 2.8 mL/kg/min), decreased the change in muscle oxygen saturation from rest to submaximal and peak exercise (∆SmO2; 2.4 ± 5.7 vs. −7.0 ± 3.4 %), and increased the relative change in deoxygenated hemoglobin/myoglobin concentration from rest to submaximal (−1.5 ± 2.3 vs. 3.0 ± 3.6 μmol/L) and peak exercise (1.1 ± 4.5 vs. 8.2 ± 3.5 μmol/L). Change in total hemoglobin/myoglobin concentration in muscle was not significantly affected by training. In CON, no significant alterations were found after 12 weeks in either muscle deoxygenation or peak VO2 (18.6 ± 3.8 vs. 18.9 ± 4.6 mL/kg/min). An increase in peak VO2 was significantly negatively correlated with change in ∆SmO2 (r = −0.65) and positively associated with change in ∆deoxy-Hb/Mb at peak exercise (r = 0.64) in TR. Conclusions: In early post-MI patients, aerobic training enhanced skeletal muscle deoxygenation, and the enhancement was related to increased aerobic capacity.

KW - Cycling training

KW - Ischemic heart disease

KW - Microcirculation

KW - Near-infrared spectroscopy

KW - Oxygen transport

UR - http://www.scopus.com/inward/record.url?scp=84954326567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954326567&partnerID=8YFLogxK

U2 - 10.1007/s00421-016-3326-x

DO - 10.1007/s00421-016-3326-x

M3 - Article

SP - 1

EP - 13

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

SN - 1439-6319

ER -