Aerobic training enhances muscle deoxygenation in early post-myocardial infarction

Shun Takagi, Norio Murase, Ryotaro Kime, Masatsugu Niwayama, Takuya Osada, Toshihito Katsumura

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Purpose: Exercise-induced skeletal muscle deoxygenation is startling by its absence in early post-myocardial infarction (MI) patients. Exercise training early post-MI is associated with reduced cardiovascular risk and increased aerobic capacity. We therefore investigated whether aerobic training could enhance the muscle deoxygenation in early post-MI patients. Methods: 21 ± 8 days after the first MI patients (n = 16) were divided into 12-week aerobic training (TR, n = 10) or non-training (CON, n = 6) groups. Before and after intervention, patients performed ramp bicycle exercise until exhaustion. Muscle deoxygenation was measured at vastus lateralis by near-infrared spectroscopy during exercise. Results: Aerobic training significantly increased peak oxygen uptake (VO2) (18.1 ± 3.0 vs. 22.9 ± 2.8 mL/kg/min), decreased the change in muscle oxygen saturation from rest to submaximal and peak exercise (∆SmO2; 2.4 ± 5.7 vs. −7.0 ± 3.4 %), and increased the relative change in deoxygenated hemoglobin/myoglobin concentration from rest to submaximal (−1.5 ± 2.3 vs. 3.0 ± 3.6 μmol/L) and peak exercise (1.1 ± 4.5 vs. 8.2 ± 3.5 μmol/L). Change in total hemoglobin/myoglobin concentration in muscle was not significantly affected by training. In CON, no significant alterations were found after 12 weeks in either muscle deoxygenation or peak VO2 (18.6 ± 3.8 vs. 18.9 ± 4.6 mL/kg/min). An increase in peak VO2 was significantly negatively correlated with change in ∆SmO2 (r = −0.65) and positively associated with change in ∆deoxy-Hb/Mb at peak exercise (r = 0.64) in TR. Conclusions: In early post-MI patients, aerobic training enhanced skeletal muscle deoxygenation, and the enhancement was related to increased aerobic capacity.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalEuropean Journal of Applied Physiology
DOIs
Publication statusAccepted/In press - 2016 Jan 12

Keywords

  • Cycling training
  • Ischemic heart disease
  • Microcirculation
  • Near-infrared spectroscopy
  • Oxygen transport

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Orthopedics and Sports Medicine
  • Physiology (medical)

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