Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA

Zsolt Radak, Zhongfu Zhao, Sataro Goto, Erika Koltai

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Lipids, proteins and DNA in the central nervous system have a high sensitivity to oxidative stress. Reactive oxygen species (ROS)-induced damage increases with aging, especially in the last quarter of the life span. The so called base level of oxidative modification of lipids could be important to cell signaling, and membrane remodeling, but the ROS-mediated post translation modifications of proteins could be important to the homeostasis of protein turnover. Low levels of 8-oxo-7,8-dihydroguanine (8-oxoG) might be necessary for transcription. A high level of accumulation of lipid peroxidation, oxidative protein damage or 8-oxoG, on the other hand, accelerates the progress of aging and neurodegenerative diseases. Therefore, agents that induce the activity of repair enzymes, such as Ca(2 +)-independent phospholipase A(2) (iPLA(2)beta), methionine sulfoxide reductase, and 8-oxoguanine DNA glycosylase, or the activity of enzymes that could prevent the accumulation of oxidized, toxic proteins, such as proteasome, Lon protease, neprilysin or insulin degrading enzyme, may act as potential therapeutic tools to slow the aging process and the progress of neurodegenerative diseases.

Original languageEnglish
Pages (from-to)305-315
Number of pages11
JournalMolecular Aspects of Medicine
Volume32
Issue number4-6
DOIs
Publication statusPublished - 2011 Aug 1
Externally publishedYes

Keywords

  • Aging
  • Hormesis
  • Oxidative damage repair
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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