Aldsulfin, a novel unusual anti-mannheimiosis epithiodiketopiperazine antibiotic produced by Lasiodiplodia pseudotheobromae FKI-4499

Kazunari Sakai, Masato Iwatsuki, Masato Iizuka, Yukihiro Asami, Kenichi Nonaka, Rokuro Masuma, Mami Takizawa, Takuji Nakashima, Toshiyuki Tokiwa, Kazuro Shiomi, Satoshi Ōmura

Research output: Contribution to journalArticlepeer-review

Abstract

An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a known compound, lasiodipline C, using bioassay-guided fractionation. Spectroscopic analysis of aldsulfin, using NMR, mass spectrometry, and CD analyses revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety. Aldsulfin showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida.

Original languageEnglish
Pages (from-to)363-369
Number of pages7
JournalJournal of Antibiotics
Volume74
Issue number6
DOIs
Publication statusPublished - 2021 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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