Alteration of inflammatory cytokine production in the injured central nervous system of tenascin-deficient mice

Hiroko Ikeshima-Kataoka, Jin Song Shen, Yoshikatsu Eto, Saburo Saito, Shigeki Yuasa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Although tenascin-C (TN) is highly up-regulated during the proliferation of reactive astrocytes, little is known about the function of TN at injury sites in the central nervous system (CNS). Here, the function of TN-expressing astrocytes in the injured brain was investigated by analyzing TN-deficient mice with stab-wound injuries of the cerebral cortex. Glial fibrillary acid protein expression after injury was down-regulated earlier in TN-deficient mice than in wild-type (WT) mice. To evaluate immune responses in the injured CNS in the absence of TN, inflammatory cytokine production was examined after unilateral stab injuries of the cerebral cortex in TN-deficient and WT mice. The expression of interleukin (IL)-1β, tumor necrosis factor-α and IL-6 was higher in TN-deficient mice, whereas levels of IL-4 and granulocyte colony-stimulating factor were lower in TN-deficient mice than WT mice. Our findings suggest that TN helps to regulate production of inflammatory cytokines in the injured brain.

Original languageEnglish
Pages (from-to)409-414
Number of pages6
JournalIn Vivo
Volume22
Issue number4
Publication statusPublished - 2008 Jul
Externally publishedYes

Keywords

  • Astrocytes
  • Central nervous system (CNS)
  • Glial fibrillary acidic protein (GFAP)
  • Lesion
  • Tenascin-C (TN)

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Alteration of inflammatory cytokine production in the injured central nervous system of tenascin-deficient mice'. Together they form a unique fingerprint.

  • Cite this

    Ikeshima-Kataoka, H., Shen, J. S., Eto, Y., Saito, S., & Yuasa, S. (2008). Alteration of inflammatory cytokine production in the injured central nervous system of tenascin-deficient mice. In Vivo, 22(4), 409-414.