Alterations in brain serotonin synthesis in male alcoholics measured using positron emission tomography

Masami Nishikawa, Mirko Diksic, Yojiro Sakai, Hiroaki Kumano, Dara Charney, Jorge Palacios-Boix, Juan Negrete, Kathryn Gill

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: A consistent association between low endogenous 5HT function and high alcohol preference has been observed, and a number of serotonergic manipulations (uptake blockers, agonists) alter alcohol consumption in animals and humans. Studies have also shown an inverse relationship between alcohol use and cerebrospinal fluid levels of serotonin metabolites, suggesting that chronic alcohol consumption produces alterations in serotonin synthesis or release. Methods: The objective of the study was to characterize regional brain serotonin synthesis in nondepressed chronic alcoholics at treatment entry in comparison to normal nonalcoholic controls using PET and the tracer α-[ 11C]-methyl-l-tryptophan. Results: Comparisons of the alcoholics and controls by SPM found that there were significant differences in the rate of serotonin synthesis between groups. Serotonin synthesis was significantly lower among alcoholics in Brodmann Area (BA) 9, 10, and 32. However, serotonin synthesis among the alcoholics group was significantly higher than controls at BA19 in the occipital lobe and around the transverse temporal convolution in the left superior temporal gyrus (BA41). In addition, there were correlations between regional serotonin synthesis and a quantity-frequency measure of alcohol consumption. Regions showing a significant negative correlation with QF included the bilateral rectus gyri (BA11) in the orbitofrontal area, the bilateral medial frontal area (BA6), and the right amygdala. Conclusions: Current alcoholism is associated with serotonergic abnormalities in brain regions that are known to be involved in planning, judgment, self-control, and emotional regulation.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume33
Issue number2
DOIs
Publication statusPublished - 2009 Feb
Externally publishedYes

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Positron emission tomography
Alcoholics
Positron-Emission Tomography
Brain
Serotonin
Alcohols
Alcohol Drinking
Cerebrospinal fluid
Occipital Lobe
Temporal Lobe
Metabolites
Amygdala
Prefrontal Cortex
Convolution
Tryptophan
Alcoholism
Cerebrospinal Fluid
Animals
Association reactions
Planning

Keywords

  • α-Methyl-L-tryptophan
  • 5HT
  • Alcoholism
  • PET
  • Positron emission tomography
  • Serotonin
  • Serotonin synthesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Alterations in brain serotonin synthesis in male alcoholics measured using positron emission tomography. / Nishikawa, Masami; Diksic, Mirko; Sakai, Yojiro; Kumano, Hiroaki; Charney, Dara; Palacios-Boix, Jorge; Negrete, Juan; Gill, Kathryn.

In: Alcoholism: Clinical and Experimental Research, Vol. 33, No. 2, 02.2009, p. 233-239.

Research output: Contribution to journalArticle

Nishikawa, Masami ; Diksic, Mirko ; Sakai, Yojiro ; Kumano, Hiroaki ; Charney, Dara ; Palacios-Boix, Jorge ; Negrete, Juan ; Gill, Kathryn. / Alterations in brain serotonin synthesis in male alcoholics measured using positron emission tomography. In: Alcoholism: Clinical and Experimental Research. 2009 ; Vol. 33, No. 2. pp. 233-239.
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