Alterations of immunoreactive beta-endorphin in the third ventricular fluid in response to electrical stimulation of the human periaqueductal gray matter

Keiichi Amano*, Koiti Kitamura, Hirotsune Kawamura, Tatsuya Tanikawa, Hiroko Kawabatake, Masao Notani, Hiroshi Iseki, Telsusi Shiwaku, Toshihiro Suda, Hiroshi Demura

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Immunoreactive beta-endorphin in the third ventricular fluid was measured in response to electrical stimulation of the periaqueductal gray matter in 8 patients with intractable pain during rostral mesencephalic reticulotomy for pain relief. In all patients, marked increase of immunoreactive beta-endorphin was observed. On the other hand, in cases of electrical stimulation of the zona incerta performed during stereoencephalotomy, in 5 patients with involuntary movement, immunoreactive beta-endorphin in the third ventricular fluid did not show any significant change. The authors conclude that the increase of immunoreactive bcta-endor- phin on electrical stimulation of the periaqueductal gray matter is not a nonspecific response to brain stimulation but a specific response in regard to cerebral localization of endorphins. Direct correlation between pain relief and periaqueductal gray stimulation is also questioned.

    Original languageEnglish
    Pages (from-to)150-158
    Number of pages9
    JournalStereotactic and Functional Neurosurgery
    Volume43
    Issue number3-5
    DOIs
    Publication statusPublished - 1980

    Keywords

    • Endorphin
    • Involuntary movement
    • Midbrain
    • Pain
    • Periaqueductal gray matter
    • Zona incerta

    ASJC Scopus subject areas

    • Surgery
    • Clinical Neurology

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