Alterations of immunoreactive beta-endorphin in the third ventricular fluid in response to electrical stimulation of the human periaqueductal gray matter

Keiichi Amano, Koiti Kitamura, Hirotsune Kawamura, Tatsuya Tanikawa, Hiroko Kawabatake, Masao Notani, Hiroshi Iseki, Telsusi Shiwaku, Toshihiro Suda, Hiroshi Demura

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Abstract

Immunoreactive beta-endorphin in the third ventricular fluid was measured in response to electrical stimulation of the periaqueductal gray matter in 8 patients with intractable pain during rostral mesencephalic reticulotomy for pain relief. In all patients, marked increase of immunoreactive beta-endorphin was observed. On the other hand, in cases of electrical stimulation of the zona incerta performed during stereoencephalotomy, in 5 patients with involuntary movement, immunoreactive beta-endorphin in the third ventricular fluid did not show any significant change. The authors conclude that the increase of immunoreactive bcta-endor- phin on electrical stimulation of the periaqueductal gray matter is not a nonspecific response to brain stimulation but a specific response in regard to cerebral localization of endorphins. Direct correlation between pain relief and periaqueductal gray stimulation is also questioned.

Original languageEnglish
Pages (from-to)150-158
Number of pages9
JournalStereotactic and Functional Neurosurgery
Volume43
Issue number3-5
DOIs
Publication statusPublished - 1980
Externally publishedYes

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Keywords

  • Endorphin
  • Involuntary movement
  • Midbrain
  • Pain
  • Periaqueductal gray matter
  • Zona incerta

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Amano, K., Kitamura, K., Kawamura, H., Tanikawa, T., Kawabatake, H., Notani, M., Iseki, H., Shiwaku, T., Suda, T., & Demura, H. (1980). Alterations of immunoreactive beta-endorphin in the third ventricular fluid in response to electrical stimulation of the human periaqueductal gray matter. Stereotactic and Functional Neurosurgery, 43(3-5), 150-158. https://doi.org/10.1159/000102468