Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice

Michihiko Iijima, Shun Yamaguchi, Gijsbertus T J Van Der Horst, Xavier Bonnefont, Hitoshi Okamura, Shigenobu Shibata

    Research output: Contribution to journalArticle

    57 Citations (Scopus)

    Abstract

    In nocturnal rodents, restricted feeding to daytime (RF) causes feeding-associated diurnal locomotor activity that persists for the next 1-2 days when food is withheld. Along with this anticipatory behavior, the expression pattern of clock genes such as mPer1 and mPer2 changes from a nocturnal to diurnal pattern in the liver and cerebral cortex but not in the suprachiasmatic nucleus (SCN). Whether the molecular clockwork, in which mCry1 and mCry2 genes are essential components, is involved in food-anticipatory circadian rhythms is unknown. In this study, we investigated the impact of the absence of mCRY products upon the locomotion pattern induced by RF. RF caused an increase in daytime activity that lasted even for 2 days after food was withheld, in wild-type and mCry1-/- mCry2-/- mice. However, RF-induced activity was less stable and appeared more gradually in mutant mice. Similar results were obtained with mice housed under constant darkness or with SCN-lesioned wild-type and mutant mice. Our data reveal that mCry proteins are basically dispensable for food-entrainable oscillation. However, it is also important to note that mCry deficiency affects the stability and development of RF-induced anticipatory locomotor activity.

    Original languageEnglish
    Pages (from-to)166-173
    Number of pages8
    JournalNeuroscience Research
    Volume52
    Issue number2
    DOIs
    Publication statusPublished - 2005 Jun

    Fingerprint

    Cryptochromes
    Locomotion
    Food
    Suprachiasmatic Nucleus
    Gene Components
    Darkness
    Circadian Rhythm
    Cerebral Cortex
    Rodentia
    Liver
    Genes
    Proteins

    Keywords

    • Anticipation
    • Circadian
    • Clock gene
    • Locomotor activity
    • Suprachiasmatic

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Iijima, M., Yamaguchi, S., Van Der Horst, G. T. J., Bonnefont, X., Okamura, H., & Shibata, S. (2005). Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice. Neuroscience Research, 52(2), 166-173. https://doi.org/10.1016/j.neures.2005.03.003

    Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice. / Iijima, Michihiko; Yamaguchi, Shun; Van Der Horst, Gijsbertus T J; Bonnefont, Xavier; Okamura, Hitoshi; Shibata, Shigenobu.

    In: Neuroscience Research, Vol. 52, No. 2, 06.2005, p. 166-173.

    Research output: Contribution to journalArticle

    Iijima, M, Yamaguchi, S, Van Der Horst, GTJ, Bonnefont, X, Okamura, H & Shibata, S 2005, 'Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice', Neuroscience Research, vol. 52, no. 2, pp. 166-173. https://doi.org/10.1016/j.neures.2005.03.003
    Iijima, Michihiko ; Yamaguchi, Shun ; Van Der Horst, Gijsbertus T J ; Bonnefont, Xavier ; Okamura, Hitoshi ; Shibata, Shigenobu. / Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice. In: Neuroscience Research. 2005 ; Vol. 52, No. 2. pp. 166-173.
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