Altered sleep spindles in delayed encephalopathy after acute carbon monoxide poisoning

Takuya Yoshiike, Masaki Nishida*, Kazuyoshi Yagishita, Tadashi Nariai, Kenji Ishii, Toru Nishikawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Delayed encephalopathy (DE) affects not only the cerebral white matter and globus pallidus but also the cortex and thalamus. However, it remains unknown whether these brain lesions alter sleep along with clinical manifestations of DE. A 46-year-old man with DE underwent repetitive hyperbaric oxygen therapy. The patient was evaluated by not only neuropsychological and neuroimaging testing but polysomnography over the clinical course. Neurological symptoms improved markedly; however, profound frontal cognitive deficits continued. The polysomnography revealed prolonged absence and delayed recovery of sleep spindles across recordings. Alterations in spindle oscillations in DE could provide further insight into sleep regulatory networks.

Original languageEnglish
Pages (from-to)913-915
Number of pages3
JournalJournal of Clinical Sleep Medicine
Issue number6
Publication statusPublished - 2016
Externally publishedYes


  • Carbon monoxide
  • Delayed encephalopathy
  • Polysomnography
  • Sleep spindle
  • Thalamocortical networks

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology


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