氢氧化铝纳米片: 结构依赖性癌症化疗药物的储运

Translated title of the contribution: Aluminum Hydroxide Nanosheets with Structure-dependent Storage and Transportation toward Cancer Chemotherapy

Xia Li, Mohamed A. Shenashen, Moataz Mekawy, Akiyoshi Taniguchi, Sherif A. Ei-Safty

Research output: Contribution to journalArticlepeer-review

Abstract

Alum has an excellent safety record and is the only licensed inorganic adjuvant for human vaccines. However, the exploration of alum nanosheets as chemotherapy drug delivery system, especially the clarification about the relationship between structures and drug loading properties, is totally insufficient. Herein, aluminum hydroxides (AlOOH) nanosheets with tunable specific surface area and pore size were synthesized by adjusting the synthesis time in the presence of triblock copolymers. The obtained materials exhibited the highest surface area about 470 m2/g. The structure-dependent chemotherapy drug loading capability for AlOOH nanosheets was observed: the higher specific surface area and pore size are, the higher amount of chemotherapy drug is loaded. AlOOH nanosheets loaded with doxorubicin showed a pH-dependent sustained release behavior with quick release in low pH about 5 and slow release in pH around 7.4. Doxorubicin-loaded AlOOH nanosheets exhibited much higher cancer cellular uptake efficiency than that in free form by flow cytometry. Moreover, doxorubicin-loaded AlOOH nanosheets with high specific surface area showed an increased cellular uptake efficiency and enhanced ratios of apoptosis and necrosis, compared with those showing low specific surface area. Therefore, AlOOH nanosheets are promising materials as chemotherapy drug delivery system.

Translated title of the contributionAluminum Hydroxide Nanosheets with Structure-dependent Storage and Transportation toward Cancer Chemotherapy
Original languageChinese (Traditional)
Pages (from-to)250-256
Number of pages7
JournalWuji Cailiao Xuebao/Journal of Inorganic Materials
Volume35
Issue number2
DOIs
Publication statusPublished - 2020 Feb 1

Keywords

  • Aluminum hydroxide
  • Cancer chemotherapy
  • Drug delivery
  • Nanosheet
  • Storage

ASJC Scopus subject areas

  • Materials Science(all)
  • Inorganic Chemistry

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