Ambient-Light-Promoted Three-Component Annulation: Synthesis of Perfluoroalkylated Pyrimidines

Rui Wang, Wei Guan, Zheng Bo Han, Fushun Liang, Takeo Suga, Xihe Bi, Hiroyuki Nishide

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

An ambient-light-promoted and metal-free three-component reaction of active methylene compounds, perfluoroalkyl iodides, and guanidines/amidines is reported. This constitutes a powerful method to prepare perfluoroalkylated pyrimidines with mild reaction conditions, broad substrate scope, excellent functional group tolerance, and simple operation. A radical/polar mechanism involving the formation of a halogen-bond adduct and radical cross-coupling is proposed.

Original languageEnglish
Pages (from-to)2358-2361
Number of pages4
JournalOrganic Letters
Volume19
Issue number9
DOIs
Publication statusPublished - 2017 May 5

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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