Amphibian prolactins: Activity in the eft skin transepithelial potential bioassay

Stephen C. Brown*, Patricia Stocking Brown, Kazutoshi Yamamoto, Kouhei Matsuda, Sakae Kikuyama

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)


    The effects of purified prolactins isolated from frogs (fPRL; Rana catesbeiana) and newts (nPRL; Cynops pyrrhogaster) were compared with those of ovine prolactin (oPRL) and thyrotropin releasing hormone (TRH) in the eft (Notophthalmus viridescens) skin transepithelial potential (TEP) bioassay. At total doses as low as 0.4 μg/animal, both fPRL and nPRL were as effective as oPRL in reducing eft skin TEP. By contrast, TRH at total doses as high as 400 μg/animal was ineffective in altering eft skin TEP. These data provide the first direct evidence that amphibian PRLs can exert significant physiological control over salamandrid integumental sodium transport.

    Original languageEnglish
    Pages (from-to)1-7
    Number of pages7
    JournalGeneral and Comparative Endocrinology
    Issue number1
    Publication statusPublished - 1991

    ASJC Scopus subject areas

    • Endocrinology


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