Amplification of chirality from extremely low to greater than 99.5 % ee by asymmetric autocatalysis

Itaru Sato; Hiroki Urabe; Saori Ishiguro; Takanori Shibata; Kenso Soai

doi:10.1002/anie.200390105

Amplification of chirality from extremely low to greater than 99.5 % ee by asymmetric autocatalysis

Itaru Sato^*, Hiroki Urabe, Saori Ishiguro, Takanori Shibata, Kenso Soai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

201 Citations (Scopus)

Abstract

"Single-handedly", in every sense of the word, the alkylation product shown catalyzes its own asymmetric formation from the corresponding aldehyde. In this way the miniscule initial enantiomeric excess of about 0.00005% was amplified to >99.5% ee after three cycles.

Original language	English
Pages (from-to)	315-317
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/anie.200390105
Publication status	Published - 2003 Jan 20
Externally published	Yes

Keywords

Alkylations
Asymmetric synthesis
Autocatalysis
Chirality
Zinc

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200390105

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abstract = "{"}Single-handedly{"}, in every sense of the word, the alkylation product shown catalyzes its own asymmetric formation from the corresponding aldehyde. In this way the miniscule initial enantiomeric excess of about 0.00005% was amplified to >99.5% ee after three cycles.",

keywords = "Alkylations, Asymmetric synthesis, Autocatalysis, Chirality, Zinc",

author = "Itaru Sato and Hiroki Urabe and Saori Ishiguro and Takanori Shibata and Kenso Soai",

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T1 - Amplification of chirality from extremely low to greater than 99.5 % ee by asymmetric autocatalysis

AU - Sato, Itaru

AU - Urabe, Hiroki

AU - Ishiguro, Saori

AU - Shibata, Takanori

AU - Soai, Kenso

PY - 2003/1/20

Y1 - 2003/1/20

N2 - "Single-handedly", in every sense of the word, the alkylation product shown catalyzes its own asymmetric formation from the corresponding aldehyde. In this way the miniscule initial enantiomeric excess of about 0.00005% was amplified to >99.5% ee after three cycles.

AB - "Single-handedly", in every sense of the word, the alkylation product shown catalyzes its own asymmetric formation from the corresponding aldehyde. In this way the miniscule initial enantiomeric excess of about 0.00005% was amplified to >99.5% ee after three cycles.

KW - Alkylations

KW - Asymmetric synthesis

KW - Autocatalysis

KW - Chirality

KW - Zinc

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DO - 10.1002/anie.200390105

M3 - Article

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ER -

Amplification of chirality from extremely low to greater than 99.5 % ee by asymmetric autocatalysis

Abstract

Keywords

ASJC Scopus subject areas

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