Amplification of chirality from extremely low to greater than 99.5 % ee by asymmetric autocatalysis

Itaru Sato, Hiroki Urabe, Saori Ishiguro, Takanori Shibata, Kenso Soai

Research output: Contribution to journalArticle

178 Citations (Scopus)


"Single-handedly", in every sense of the word, the alkylation product shown catalyzes its own asymmetric formation from the corresponding aldehyde. In this way the miniscule initial enantiomeric excess of about 0.00005% was amplified to >99.5% ee after three cycles.

Original languageEnglish
Pages (from-to)315-317
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number3
Publication statusPublished - 2003 Jan 20



  • Alkylations
  • Asymmetric synthesis
  • Autocatalysis
  • Chirality
  • Zinc

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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