Amplification of chirality from extremely low to greater than 99.5 % ee by asymmetric autocatalysis

Itaru Sato, Hiroki Urabe, Saori Ishiguro, Takanori Shibata, Kenso Soai

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

"Single-handedly", in every sense of the word, the alkylation product shown catalyzes its own asymmetric formation from the corresponding aldehyde. In this way the miniscule initial enantiomeric excess of about 0.00005% was amplified to >99.5% ee after three cycles.

Original languageEnglish
Pages (from-to)315-317
Number of pages3
JournalAngewandte Chemie - International Edition
Volume42
Issue number3
DOIs
Publication statusPublished - 2003 Jan 20
Externally publishedYes

Fingerprint

Chirality
Alkylation
Aldehydes
Amplification

Keywords

  • Alkylations
  • Asymmetric synthesis
  • Autocatalysis
  • Chirality
  • Zinc

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Amplification of chirality from extremely low to greater than 99.5 % ee by asymmetric autocatalysis. / Sato, Itaru; Urabe, Hiroki; Ishiguro, Saori; Shibata, Takanori; Soai, Kenso.

In: Angewandte Chemie - International Edition, Vol. 42, No. 3, 20.01.2003, p. 315-317.

Research output: Contribution to journalArticle

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