An 8-week ketogenic low carbohydrate, high fat diet enhanced exhaustive exercise capacity in mice

Sihui Ma, Qingyi Huang, Koichi Yada, Chunhong Liu, Katsuhiko Suzuki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Current fueling tactics for endurance exercise encourage athletes to ingest a high carbohydrate diet. However, athletes are not generally encouraged to use fat, the largest energy reserve in the human body. A low carbohydrate, high fat ketogenic diet (KD) is a nutritional approach ensuring that the body utilizes lipids. Although KD has been associated with weight-loss, enhanced fat utilization in muscle and other beneficial effects, there is currently no clear proof whether it could lead to performance advantage. To evaluate the effects of KD on endurance exercise capacity, we studied the performance of mice subjected to a running model after consuming KD for eight weeks. Weight dropped dramatically in KD-feeding mice, even though they ate more calories. KD-feeding mice showed enhanced running time without aggravated muscle injury. Blood biochemistry and correlation analysis indicated the potential mechanism is likely to be a keto-adaptation enhanced capacity to transport and metabolize fat. KD also showed a potential preventive effect on organ injury caused by acute exercise, although KD failed to exert protection from muscle injury. Ultimately, KD may contribute to prolonged exercise capacity.

Original languageEnglish
Article number673
JournalNutrients
Volume10
Issue number6
DOIs
Publication statusPublished - 2018 Jun 1

Fingerprint

Ketogenic Diet
High Fat Diet
high fat diet
exercise
Carbohydrates
Exercise
carbohydrates
mice
athletes
Fats
Athletes
Muscles
muscles
Wounds and Injuries
lipids
ketogenic diet
high carbohydrate diet
blood chemistry
Human Body
Running

Keywords

  • Endurance exercise capacity
  • Keto-adaptation
  • Ketogenic diet
  • Muscle damage

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

An 8-week ketogenic low carbohydrate, high fat diet enhanced exhaustive exercise capacity in mice. / Ma, Sihui; Huang, Qingyi; Yada, Koichi; Liu, Chunhong; Suzuki, Katsuhiko.

In: Nutrients, Vol. 10, No. 6, 673, 01.06.2018.

Research output: Contribution to journalArticle

Ma, Sihui ; Huang, Qingyi ; Yada, Koichi ; Liu, Chunhong ; Suzuki, Katsuhiko. / An 8-week ketogenic low carbohydrate, high fat diet enhanced exhaustive exercise capacity in mice. In: Nutrients. 2018 ; Vol. 10, No. 6.
@article{84b49a3edb6549bbb094fcb6f172d038,
title = "An 8-week ketogenic low carbohydrate, high fat diet enhanced exhaustive exercise capacity in mice",
abstract = "Current fueling tactics for endurance exercise encourage athletes to ingest a high carbohydrate diet. However, athletes are not generally encouraged to use fat, the largest energy reserve in the human body. A low carbohydrate, high fat ketogenic diet (KD) is a nutritional approach ensuring that the body utilizes lipids. Although KD has been associated with weight-loss, enhanced fat utilization in muscle and other beneficial effects, there is currently no clear proof whether it could lead to performance advantage. To evaluate the effects of KD on endurance exercise capacity, we studied the performance of mice subjected to a running model after consuming KD for eight weeks. Weight dropped dramatically in KD-feeding mice, even though they ate more calories. KD-feeding mice showed enhanced running time without aggravated muscle injury. Blood biochemistry and correlation analysis indicated the potential mechanism is likely to be a keto-adaptation enhanced capacity to transport and metabolize fat. KD also showed a potential preventive effect on organ injury caused by acute exercise, although KD failed to exert protection from muscle injury. Ultimately, KD may contribute to prolonged exercise capacity.",
keywords = "Endurance exercise capacity, Keto-adaptation, Ketogenic diet, Muscle damage",
author = "Sihui Ma and Qingyi Huang and Koichi Yada and Chunhong Liu and Katsuhiko Suzuki",
year = "2018",
month = "6",
day = "1",
doi = "10.3390/nu10060673",
language = "English",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",

}

TY - JOUR

T1 - An 8-week ketogenic low carbohydrate, high fat diet enhanced exhaustive exercise capacity in mice

AU - Ma, Sihui

AU - Huang, Qingyi

AU - Yada, Koichi

AU - Liu, Chunhong

AU - Suzuki, Katsuhiko

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Current fueling tactics for endurance exercise encourage athletes to ingest a high carbohydrate diet. However, athletes are not generally encouraged to use fat, the largest energy reserve in the human body. A low carbohydrate, high fat ketogenic diet (KD) is a nutritional approach ensuring that the body utilizes lipids. Although KD has been associated with weight-loss, enhanced fat utilization in muscle and other beneficial effects, there is currently no clear proof whether it could lead to performance advantage. To evaluate the effects of KD on endurance exercise capacity, we studied the performance of mice subjected to a running model after consuming KD for eight weeks. Weight dropped dramatically in KD-feeding mice, even though they ate more calories. KD-feeding mice showed enhanced running time without aggravated muscle injury. Blood biochemistry and correlation analysis indicated the potential mechanism is likely to be a keto-adaptation enhanced capacity to transport and metabolize fat. KD also showed a potential preventive effect on organ injury caused by acute exercise, although KD failed to exert protection from muscle injury. Ultimately, KD may contribute to prolonged exercise capacity.

AB - Current fueling tactics for endurance exercise encourage athletes to ingest a high carbohydrate diet. However, athletes are not generally encouraged to use fat, the largest energy reserve in the human body. A low carbohydrate, high fat ketogenic diet (KD) is a nutritional approach ensuring that the body utilizes lipids. Although KD has been associated with weight-loss, enhanced fat utilization in muscle and other beneficial effects, there is currently no clear proof whether it could lead to performance advantage. To evaluate the effects of KD on endurance exercise capacity, we studied the performance of mice subjected to a running model after consuming KD for eight weeks. Weight dropped dramatically in KD-feeding mice, even though they ate more calories. KD-feeding mice showed enhanced running time without aggravated muscle injury. Blood biochemistry and correlation analysis indicated the potential mechanism is likely to be a keto-adaptation enhanced capacity to transport and metabolize fat. KD also showed a potential preventive effect on organ injury caused by acute exercise, although KD failed to exert protection from muscle injury. Ultimately, KD may contribute to prolonged exercise capacity.

KW - Endurance exercise capacity

KW - Keto-adaptation

KW - Ketogenic diet

KW - Muscle damage

UR - http://www.scopus.com/inward/record.url?scp=85047810827&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047810827&partnerID=8YFLogxK

U2 - 10.3390/nu10060673

DO - 10.3390/nu10060673

M3 - Article

C2 - 29799502

AN - SCOPUS:85047810827

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 6

M1 - 673

ER -